TY - JOUR
T1 - Evolution of the tan Locus Contributed to Pigment Loss in Drosophila santomea
T2 - A Response to Matute et al.
AU - Rebeiz, Mark
AU - Ramos-Womack, Margarita
AU - Jeong, Sangyun
AU - Andolfatto, Peter
AU - Werner, Thomas
AU - True, John
AU - Stern, David L.
AU - Carroll, Sean B.
N1 - Funding Information:
This work was supported by National Institutes of Health (NIH) Postdoctoral Fellowship F32-GM78972 (M.R.); the Balzan Foundation, a National Science Foundation (NSF) Doctoral Dissertation Improvement Grant (M.R.-W.), and Harold W. Dodds Honorific Fellowship 2008–2009 (M.R.-W.); NIH grant GM063622-06A1 and NSF grant IOS-0640339 (D.L.S,); and the Howard Hughes Medical Institute (S.B.C. and D.L.S.).
PY - 2009/12/11
Y1 - 2009/12/11
N2 - We have shown previously that the loss of abdominal pigmentation in D. santomea relative to its sister species D. yakuba resulted, in part, from cis-regulatory mutations at the tan locus. Matute et al. claim, based solely upon extrapolation from genetic crosses of D. santomea and D. melanogaster, a much more divergent species, that at least four X chromosome regions but not tan are responsible for pigmentation differences. Here, we provide additional evidence from introgressions of D. yakuba genes into D. santomea that support a causative role for tan in the loss of pigmentation and present analyses that contradict Matute et al.'s claims. We discuss how the choice of parental species and other factors affect the ability to identify loci responsible for species divergence, and we affirm that all of our previously reported results and conclusions stand.
AB - We have shown previously that the loss of abdominal pigmentation in D. santomea relative to its sister species D. yakuba resulted, in part, from cis-regulatory mutations at the tan locus. Matute et al. claim, based solely upon extrapolation from genetic crosses of D. santomea and D. melanogaster, a much more divergent species, that at least four X chromosome regions but not tan are responsible for pigmentation differences. Here, we provide additional evidence from introgressions of D. yakuba genes into D. santomea that support a causative role for tan in the loss of pigmentation and present analyses that contradict Matute et al.'s claims. We discuss how the choice of parental species and other factors affect the ability to identify loci responsible for species divergence, and we affirm that all of our previously reported results and conclusions stand.
KW - DEVBIO
KW - EVO_ECOL
UR - http://www.scopus.com/inward/record.url?scp=71149115250&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=71149115250&partnerID=8YFLogxK
U2 - 10.1016/j.cell.2009.11.004
DO - 10.1016/j.cell.2009.11.004
M3 - Article
C2 - 20005811
AN - SCOPUS:71149115250
SN - 0092-8674
VL - 139
SP - 1189
EP - 1196
JO - Cell
JF - Cell
IS - 6
ER -