Evolution of equine influenza virus in vaccinated horses

Pablo R. Murcia, Gregory J. Baillie, J. Conrad Stack, Carley Jervis, Debra Elton, Jennifer A. Mumford, Janet Daly, Paul Kellam, Bryan T. Grenfell, Edward C. Holmes, James L.N. Wood

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Influenza A viruses are characterized by their ability to evade host immunity, even in vaccinated individuals. To determine how prior immunity shapes viral diversity in vivo, we studied the intra- and interhost evolution of equine influenza virus in vaccinated horses. Although the level and structure of genetic diversity were similar to those in naïve horses, intrahost bottlenecks may be more stringent in vaccinated animals, and mutations shared among horses often fall close to putative antigenic sites.

Original languageEnglish (US)
Pages (from-to)4768-4771
Number of pages4
JournalJournal of virology
Volume87
Issue number8
DOIs
StatePublished - Apr 2013

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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  • Cite this

    Murcia, P. R., Baillie, G. J., Stack, J. C., Jervis, C., Elton, D., Mumford, J. A., Daly, J., Kellam, P., Grenfell, B. T., Holmes, E. C., & Wood, J. L. N. (2013). Evolution of equine influenza virus in vaccinated horses. Journal of virology, 87(8), 4768-4771. https://doi.org/10.1128/JVI.03379-12