Evidence that focal adhesion complexes power bacterial gliding motility

Tâm Mignot; Joshua W. Shaevitz; Patricia L. Hartzell; David R. Zusman

doi:10.1126/science.1137223

Evidence that focal adhesion complexes power bacterial gliding motility

Tâm Mignot, Joshua W. Shaevitz, Patricia L. Hartzell, David R. Zusman

Research output: Contribution to journal › Article › peer-review

183 Scopus citations

Abstract

The bacterium Myxococcus xanthus has two motility systems: S motility, which is powered by type IV pilus retraction, and A motility, which is powered by unknown mechanism(s). We found that A motility involved transient adhesion complexes that remained at fixed positions relative to the substratum as cells moved forward. Complexes assembled at leading cell poles and dispersed at the rear of the cells. When cells reversed direction, the A-motility clusters relocalized to the new leading poles together with S-motility proteins. The Frz chemosensory system coordinated the two motility systems. The dynamics of protein cluster localization suggest that intracellular motors and force transmission by dynamic focal adhesions can power bacterial motility.

Original language	English (US)
Pages (from-to)	853-856
Number of pages	4
Journal	Science
Volume	315
Issue number	5813
DOIs	https://doi.org/10.1126/science.1137223
State	Published - Feb 9 2007
Externally published	Yes

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10.1126/science.1137223

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title = "Evidence that focal adhesion complexes power bacterial gliding motility",

abstract = "The bacterium Myxococcus xanthus has two motility systems: S motility, which is powered by type IV pilus retraction, and A motility, which is powered by unknown mechanism(s). We found that A motility involved transient adhesion complexes that remained at fixed positions relative to the substratum as cells moved forward. Complexes assembled at leading cell poles and dispersed at the rear of the cells. When cells reversed direction, the A-motility clusters relocalized to the new leading poles together with S-motility proteins. The Frz chemosensory system coordinated the two motility systems. The dynamics of protein cluster localization suggest that intracellular motors and force transmission by dynamic focal adhesions can power bacterial motility.",

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AU - Mignot, Tâm

AU - Shaevitz, Joshua W.

AU - Hartzell, Patricia L.

AU - Zusman, David R.

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Y1 - 2007/2/9

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AB - The bacterium Myxococcus xanthus has two motility systems: S motility, which is powered by type IV pilus retraction, and A motility, which is powered by unknown mechanism(s). We found that A motility involved transient adhesion complexes that remained at fixed positions relative to the substratum as cells moved forward. Complexes assembled at leading cell poles and dispersed at the rear of the cells. When cells reversed direction, the A-motility clusters relocalized to the new leading poles together with S-motility proteins. The Frz chemosensory system coordinated the two motility systems. The dynamics of protein cluster localization suggest that intracellular motors and force transmission by dynamic focal adhesions can power bacterial motility.

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Evidence that focal adhesion complexes power bacterial gliding motility

Abstract

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