Evaluation on the use of confined liquid impinging jets for the synthesis of nanodrug particles

Herbert Chiou; Hak Kim Chan; Robert K. Prud'homme; Judy A. Raper

doi:10.1080/03639040701508011

Evaluation on the use of confined liquid impinging jets for the synthesis of nanodrug particles

Herbert Chiou, Hak Kim Chan, Robert K. Prud'homme, Judy A. Raper

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Most pharmaceutical compounds can benefit from being produced with a small particle size to enhance processing or therapeutic performance. Confined liquid impinging jets (CLIJ) were employed in this study to evaluate the feasibility and limitations in the production of nanodrugs (i.e., particle size in the nanorange). Four drugs from different pharmaceutical classes and water solubilities - salbutamol sulfate, mannitol, ibuprofen, and cyclosporine - were examined. Particles of salbutamol sulfate and cyclosporine with diameters of approximately 300 nm were successfully achieved. The use of CLIJ thus shows potential in the production of nanopharmaceuticals for certain compounds.

Original language	English (US)
Pages (from-to)	59-64
Number of pages	6
Journal	Drug Development and Industrial Pharmacy
Volume	34
Issue number	1
DOIs	https://doi.org/10.1080/03639040701508011
State	Published - Jan 2008

All Science Journal Classification (ASJC) codes

Drug Discovery
Pharmacology
Pharmaceutical Science
Organic Chemistry

Keywords

Confined liquid impinging jet
Crystallization
Drug delivery
Nanodrug
Nanoparticle

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10.1080/03639040701508011

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title = "Evaluation on the use of confined liquid impinging jets for the synthesis of nanodrug particles",

abstract = "Most pharmaceutical compounds can benefit from being produced with a small particle size to enhance processing or therapeutic performance. Confined liquid impinging jets (CLIJ) were employed in this study to evaluate the feasibility and limitations in the production of nanodrugs (i.e., particle size in the nanorange). Four drugs from different pharmaceutical classes and water solubilities - salbutamol sulfate, mannitol, ibuprofen, and cyclosporine - were examined. Particles of salbutamol sulfate and cyclosporine with diameters of approximately 300 nm were successfully achieved. The use of CLIJ thus shows potential in the production of nanopharmaceuticals for certain compounds.",

keywords = "Confined liquid impinging jet, Crystallization, Drug delivery, Nanodrug, Nanoparticle",

author = "Herbert Chiou and Chan, {Hak Kim} and Prud'homme, {Robert K.} and Raper, {Judy A.}",

note = "Funding Information: This work is supported by the Australian Research Council (DP0451940). The authors would like to thank Ms. Elisabeth Schmitz for measuring the PSD of mannitol and Dr. Patricia Tang for obtaining the SEM image of mannitol. One of the authors, Judy A. Raper, is located at the National Science Foundation. Any opinion, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation.",

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doi = "10.1080/03639040701508011",

language = "English (US)",

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AU - Chan, Hak Kim

AU - Prud'homme, Robert K.

AU - Raper, Judy A.

N1 - Funding Information: This work is supported by the Australian Research Council (DP0451940). The authors would like to thank Ms. Elisabeth Schmitz for measuring the PSD of mannitol and Dr. Patricia Tang for obtaining the SEM image of mannitol. One of the authors, Judy A. Raper, is located at the National Science Foundation. Any opinion, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation.

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KW - Confined liquid impinging jet

KW - Crystallization

KW - Drug delivery

KW - Nanodrug

KW - Nanoparticle

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Evaluation on the use of confined liquid impinging jets for the synthesis of nanodrug particles

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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