Evaluation on the use of confined liquid impinging jets for the synthesis of nanodrug particles

Herbert Chiou, Hak Kim Chan, Robert K. Prud'homme, Judy A. Raper

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Most pharmaceutical compounds can benefit from being produced with a small particle size to enhance processing or therapeutic performance. Confined liquid impinging jets (CLIJ) were employed in this study to evaluate the feasibility and limitations in the production of nanodrugs (i.e., particle size in the nanorange). Four drugs from different pharmaceutical classes and water solubilities - salbutamol sulfate, mannitol, ibuprofen, and cyclosporine - were examined. Particles of salbutamol sulfate and cyclosporine with diameters of approximately 300 nm were successfully achieved. The use of CLIJ thus shows potential in the production of nanopharmaceuticals for certain compounds.

Original languageEnglish (US)
Pages (from-to)59-64
Number of pages6
JournalDrug Development and Industrial Pharmacy
Issue number1
StatePublished - Jan 2008

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry


  • Confined liquid impinging jet
  • Crystallization
  • Drug delivery
  • Nanodrug
  • Nanoparticle


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