TY - JOUR
T1 - Estimating sources and sinks of malaria parasites in Madagascar
AU - Ihantamalala, Felana Angella
AU - Herbreteau, Vincent
AU - Rakotoarimanana, Feno M.J.
AU - Rakotondramanga, Jean Marius
AU - Cauchemez, Simon
AU - Rahoilijaona, Bienvenue
AU - Pennober, Gwenaëlle
AU - Buckee, Caroline O.
AU - Rogier, Christophe
AU - Metcalf, C. J.E.
AU - Wesolowski, Amy
N1 - Publisher Copyright:
© 2018, The Author(s).
PY - 2018/12/1
Y1 - 2018/12/1
N2 - In areas where malaria epidemiology is spatially and temporally heterogeneous, human-mediated parasite importation can result in non-locally acquired clinical cases and outbreaks in low-transmission areas. Using mobility estimates derived from the mobile phone data and spatial malaria prevalence data, we identify travel routes relevant to malaria transmission in Madagascar. We find that the primary hubs of parasite importation are in a spatially connected area of the central highlands. Surprisingly, sources of these imported infections are not spatially clustered. We then related these source locations directly to clinical cases in the low-transmission area of the capital. We find that in the capital, a major sink, the primary sources of infection are along the more populated coastal areas, although these sources are seasonally variable. Our results have implications for targeting interventions at source locations to achieve local or national malaria control goals.
AB - In areas where malaria epidemiology is spatially and temporally heterogeneous, human-mediated parasite importation can result in non-locally acquired clinical cases and outbreaks in low-transmission areas. Using mobility estimates derived from the mobile phone data and spatial malaria prevalence data, we identify travel routes relevant to malaria transmission in Madagascar. We find that the primary hubs of parasite importation are in a spatially connected area of the central highlands. Surprisingly, sources of these imported infections are not spatially clustered. We then related these source locations directly to clinical cases in the low-transmission area of the capital. We find that in the capital, a major sink, the primary sources of infection are along the more populated coastal areas, although these sources are seasonally variable. Our results have implications for targeting interventions at source locations to achieve local or national malaria control goals.
UR - http://www.scopus.com/inward/record.url?scp=85053827331&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85053827331&partnerID=8YFLogxK
U2 - 10.1038/s41467-018-06290-2
DO - 10.1038/s41467-018-06290-2
M3 - Article
C2 - 30254280
AN - SCOPUS:85053827331
SN - 2041-1723
VL - 9
JO - Nature communications
JF - Nature communications
IS - 1
M1 - 3897
ER -