Epithelial-mesenchymal transitions: Twist in development and metastasis

Yibin Kang; Joan Massagué

doi:10.1016/j.cell.2004.07.011

Epithelial-mesenchymal transitions: Twist in development and metastasis

Yibin Kang, Joan Massagué

Research output: Contribution to journal › Review article › peer-review

1325 Scopus citations

Abstract

Epithelial-mesenchymal transitions (EMT) are vital for morphogenesis during embryonic development and are also implicated in the conversion of early stage tumors into invasive malignancies. Several key inducers of EMT are transcription factors that repress E-cadherin expression. A recent report in Cell (Yang et al., 2004) adds Twist to this list and links EMT to the ability of breast cancer cells to enter the circulation and seed metastases.

Original language	English (US)
Pages (from-to)	277-279
Number of pages	3
Journal	Cell
Volume	118
Issue number	3
DOIs	https://doi.org/10.1016/j.cell.2004.07.011
State	Published - Aug 6 2004
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2004.07.011

Cite this

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title = "Epithelial-mesenchymal transitions: Twist in development and metastasis",

abstract = "Epithelial-mesenchymal transitions (EMT) are vital for morphogenesis during embryonic development and are also implicated in the conversion of early stage tumors into invasive malignancies. Several key inducers of EMT are transcription factors that repress E-cadherin expression. A recent report in Cell (Yang et al., 2004) adds Twist to this list and links EMT to the ability of breast cancer cells to enter the circulation and seed metastases.",

author = "Yibin Kang and Joan Massagu{\'e}",

year = "2004",

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doi = "10.1016/j.cell.2004.07.011",

language = "English (US)",

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T2 - Twist in development and metastasis

AU - Kang, Yibin

AU - Massagué, Joan

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Y1 - 2004/8/6

N2 - Epithelial-mesenchymal transitions (EMT) are vital for morphogenesis during embryonic development and are also implicated in the conversion of early stage tumors into invasive malignancies. Several key inducers of EMT are transcription factors that repress E-cadherin expression. A recent report in Cell (Yang et al., 2004) adds Twist to this list and links EMT to the ability of breast cancer cells to enter the circulation and seed metastases.

AB - Epithelial-mesenchymal transitions (EMT) are vital for morphogenesis during embryonic development and are also implicated in the conversion of early stage tumors into invasive malignancies. Several key inducers of EMT are transcription factors that repress E-cadherin expression. A recent report in Cell (Yang et al., 2004) adds Twist to this list and links EMT to the ability of breast cancer cells to enter the circulation and seed metastases.

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U2 - 10.1016/j.cell.2004.07.011

DO - 10.1016/j.cell.2004.07.011

M3 - Review article

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VL - 118

SP - 277

EP - 279

JO - Cell

JF - Cell

IS - 3

ER -

Epithelial-mesenchymal transitions: Twist in development and metastasis

Abstract

All Science Journal Classification (ASJC) codes

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