Epithelial-mesenchymal transitions: Twist in development and metastasis

Yibin Kang, Joan Massagué

Research output: Contribution to journalReview articlepeer-review

1303 Scopus citations


Epithelial-mesenchymal transitions (EMT) are vital for morphogenesis during embryonic development and are also implicated in the conversion of early stage tumors into invasive malignancies. Several key inducers of EMT are transcription factors that repress E-cadherin expression. A recent report in Cell (Yang et al., 2004) adds Twist to this list and links EMT to the ability of breast cancer cells to enter the circulation and seed metastases.

Original languageEnglish (US)
Pages (from-to)277-279
Number of pages3
Issue number3
StatePublished - Aug 6 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology


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