Epithelial Engineering: From Sheets to Branched Tubes

Hye Young Kim, Celeste M. Nelson

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The epithelium is one of the major tissue types in the body, commonly arranged as either a single layer or multiple layers of cells. Construction of the basic structure and function of the epithelium begins during development, when populations of epithelial cells undergo dramatic changes in shape. This chapter introduces examples of epithelial morphogenesis that occur in nature which can provide useful insights into how epithelial tissues sculpt themselves into various shapes. The chapter also highlights engineering strategies that can be used to dissect the effects of the individual regulatory components by mimicking external environments and various stimuli during epithelial sheet migration, folding, tubulogenesis, and branching. The chapter describes current engineering approaches that were inspired from epithelial morphogenesis in vivo, and used to uncover additional processes involved in building various shapes of epithelial tissues.

Original languageEnglish (US)
Title of host publicationBio-inspired Materials for Biomedical Engineering
PublisherWiley-Blackwell
Pages161-173
Number of pages13
Volume9781118369364
ISBN (Electronic)9781118843499
ISBN (Print)9781118369364
DOIs
StatePublished - Apr 14 2014

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)
  • Materials Science(all)
  • Chemical Engineering(all)

Keywords

  • Epithelial engineering
  • Epithelial tubes
  • Mimic epithelial morphogenesis

Fingerprint Dive into the research topics of 'Epithelial Engineering: From Sheets to Branched Tubes'. Together they form a unique fingerprint.

  • Cite this

    Kim, H. Y., & Nelson, C. M. (2014). Epithelial Engineering: From Sheets to Branched Tubes. In Bio-inspired Materials for Biomedical Engineering (Vol. 9781118369364, pp. 161-173). Wiley-Blackwell. https://doi.org/10.1002/9781118843499.ch10