Epigenetics and Understanding the Impact of Social Determinants of Health

Daniel A. Notterman, Colter Mitchell

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

Recently, a new research agenda emphasizing interactions between social factors and health has emerged. The term social determinant of health often refers to any nonmedical factor directly influencing health. Health across the life span is strongly and adversely affected by social disadvantage. Research in epigenetics indicates that alterations in DNA methylation may provide a causal link between social adversity and health disparity. Likewise, accelerated loss of telomeres is correlated with chronic stress. Research is still required to develop an understanding of the role of epigenetics and perturbed telomere function in linking social adversity with health outcome.

Original languageEnglish (US)
Pages (from-to)1227-1240
Number of pages14
JournalPediatric Clinics of North America
Volume62
Issue number5
DOIs
StatePublished - Oct 1 2015

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Keywords

  • DNA
  • Epigenetics
  • Health disparity
  • Methylation
  • Social disparity
  • Telomere

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