TY - JOUR
T1 - Epigenetic influences on brain development and plasticity
AU - Fagiolini, Michela
AU - Jensen, Catherine L.
AU - Champagne, Frances A.
PY - 2009/4
Y1 - 2009/4
N2 - A fine interplay exists between sensory experience and innate genetic programs leading to the sculpting of neuronal circuits during early brain development. Recent evidence suggests that the dynamic regulation of gene expression through epigenetic mechanisms is at the interface between environmental stimuli and long lasting molecular, cellular and complex behavioral phenotypes acquired during periods of developmental plasticity. Understanding these mechanisms may give insight into the formation of critical periods and provide new strategies for increasing plasticity and adaptive change in adulthood.
AB - A fine interplay exists between sensory experience and innate genetic programs leading to the sculpting of neuronal circuits during early brain development. Recent evidence suggests that the dynamic regulation of gene expression through epigenetic mechanisms is at the interface between environmental stimuli and long lasting molecular, cellular and complex behavioral phenotypes acquired during periods of developmental plasticity. Understanding these mechanisms may give insight into the formation of critical periods and provide new strategies for increasing plasticity and adaptive change in adulthood.
UR - http://www.scopus.com/inward/record.url?scp=67650762717&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67650762717&partnerID=8YFLogxK
U2 - 10.1016/j.conb.2009.05.009
DO - 10.1016/j.conb.2009.05.009
M3 - Review article
C2 - 19545993
AN - SCOPUS:67650762717
SN - 0959-4388
VL - 19
SP - 207
EP - 212
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
IS - 2
ER -