Epigenetic influences on brain development and plasticity

Michela Fagiolini, Catherine L. Jensen, Frances A. Champagne

Research output: Contribution to journalReview article

195 Scopus citations

Abstract

A fine interplay exists between sensory experience and innate genetic programs leading to the sculpting of neuronal circuits during early brain development. Recent evidence suggests that the dynamic regulation of gene expression through epigenetic mechanisms is at the interface between environmental stimuli and long lasting molecular, cellular and complex behavioral phenotypes acquired during periods of developmental plasticity. Understanding these mechanisms may give insight into the formation of critical periods and provide new strategies for increasing plasticity and adaptive change in adulthood.

Original languageEnglish (US)
Pages (from-to)207-212
Number of pages6
JournalCurrent Opinion in Neurobiology
Volume19
Issue number2
DOIs
StatePublished - Apr 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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