@article{3d945b61c3674b15aa0424203b38498b,
title = "Epigenetic control of innate and adaptive immune memory",
abstract = "Clonal expansion and immunological memory are hallmark features of the mammalian adaptive immune response and essential for prolonged host control of pathogens. Recent work demonstrates that natural killer (NK) cells of the innate immune system also exhibit these adaptive traits during infection. Here we demonstrate that differentiating and {\textquoteleft}memory{\textquoteright} NK cells possess distinct chromatin accessibility states and that their epigenetic profiles reveal a {\textquoteleft}poised{\textquoteright} regulatory program at the memory stage. Furthermore, we elucidate how individual STAT transcription factors differentially control epigenetic and transcriptional states early during infection. Finally, concurrent chromatin profiling of the canonical CD8+ T cell response against the same infection demonstrated parallel and distinct epigenetic signatures defining NK cells and CD8+ T cells. Overall, our study reveals the dynamic nature of epigenetic modifications during the generation of innate and adaptive lymphocyte memory.",
author = "Lau, {Colleen M.} and Adams, {Nicholas M.} and Geary, {Clair D.} and Weizman, {Orr El} and Moritz Rapp and Yuri Pritykin and Leslie, {Christina S.} and Sun, {Joseph C.}",
note = "Funding Information: We thank members of the Sun laboratory for comments, discussions, technical support, and experimental assistance. We thank S. Chhangawala, L. Fairchild, and C. Krishna for discussions and technical support. The Integrated Genomics Operation Core was supported by Cycle for Survival and the Marie-Jos{\'e}e and Henry R. Kravis Center for Molecular Oncology. C.M.L. was supported by a T32 award from the NIH (CA009149). N.M.A. was supported by a Medical Scientist Training Program grant from the National Institute of General Medical Sciences of the NIH under award number T32GM007739 to the Weill Cornell/Rockefeller/Sloan-Kettering Tri-Institutional MD-PhD Program and an F30 Predoctoral Fellowship from the NIH National Institute of Allergy and Infectious Diseases (F30 AI136239). M.R. was supported by a fellowship from the German Academic Exchange Service (DAAD; Germany). C.S.L. was supported by NIH grant U01 HG007893. J.C.S. was supported by the Ludwig Center for Cancer Immunotherapy, the Burroughs Wellcome Fund, the American Cancer Society, and grants from the NIH (AI100874, AI130043, and P30CA008748). Publisher Copyright: {\textcopyright} 2018, The Author(s).",
year = "2018",
month = sep,
day = "1",
doi = "10.1038/s41590-018-0176-1",
language = "English (US)",
volume = "19",
pages = "963--972",
journal = "Nature Immunology",
issn = "1529-2908",
publisher = "Nature Publishing Group",
number = "9",
}