Epidermal growth factor signalling and bone metastasis

X. Lu, Y. Kang

Research output: Contribution to journalShort survey

48 Scopus citations

Abstract

Epidermal growth factor (EGF) signalling is well known for its multifaceted functions in development and tissue homoeostasis. The EGF family of ligands and receptors (ERBB family) have also been extensively investigated for their roles in promoting tumourigenesis and metastasis in a variety of cancer types. Recent findings indicate that EGF signalling is an important mediator of bone metastasis in breast, prostate and kidney cancers. The EGF signalling stimulates the growth of bone metastasis directly by increasing tumour cell proliferation and indirectly by engaging bone stromal cell in metastasis-promoting activities. Therefore, molecular targeting of ERBB receptors may benefit patients with bone metastasis and should be evaluated in clinical trials.

Original languageEnglish (US)
Pages (from-to)457-461
Number of pages5
JournalBritish Journal of Cancer
Volume102
Issue number3
DOIs
StatePublished - Feb 2010

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Keywords

  • Bone metastasis
  • EGF
  • ERBB
  • Metalloproteinase
  • Osteoblast
  • Osteoclast

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