Epidemiological impact of vaccination on the dynamics of two childhood diseases in rural Senegal

Hélène Broutin, Natalia B. Mantilla-Beniers, François Simondon, Peter Aaby, Bryan T. Grenfell, Jean François Guégan, Pejman Rohani

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Measles and pertussis are ubiquitous vaccine-preventable diseases, which remain an important public health problem in developing countries. Hence, developing a deep understanding of their transmission dynamics remains imperative. To achieve this, we compared the impact of vaccination at both individual and population levels in a Senegalese rural community. This study represents the first such comparative study in tropical conditions and constitutes a point of comparison with other studies of disease dynamics in developed countries. Changes in the transmission rates of infections are reflected in their mean ages at infection and basic reproductive ratio calculated before and after vaccination. We explored persistence of both infections in relation to population size in each village and found the inter-epidemic period for the whole area using wavelets analysis. As predicted by epidemiological theory, we observed an increase in the mean age at infection and a decrease in the reproductive ratio of both diseases. We showed for both the pre- vaccination and vaccine eras that persistence depends on population size. After vaccination, persistence decreased and the inter-epidemic period increased. The observed changes suggest that vaccination against measles and pertussis induced a drop in their transmission. Similarities in disease dynamics to those of temperate regions such as England and Wales were also observed.

Original languageEnglish (US)
Pages (from-to)593-599
Number of pages7
JournalMicrobes and Infection
Volume7
Issue number4
DOIs
StatePublished - Apr 1 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Infectious Diseases

Keywords

  • Measles
  • Persistence
  • Pertussis
  • Population dynamics
  • Senegal
  • Transmission
  • Vaccination

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