Enzymic Regioselectivity in the Hydroxylation of Cholesterol Catalyzed by a Membrane-Spanning Metalloporphyrin

John Taylor Groves; Ronny Neumann

doi:10.1021/jo00251a054

Enzymic Regioselectivity in the Hydroxylation of Cholesterol Catalyzed by a Membrane-Spanning Metalloporphyrin

John Taylor Groves, Ronny Neumann

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63 Scopus citations

Abstract

The hydroxylation of simple alkanes and the selective C-25 hydroxylation of cholesterol have been achieved with a membrane-spanning Mn(III) porphyrin positioned in a synthetic bilayer assembly by appended steroidal substituents.

Original language	English (US)
Pages (from-to)	3891-3893
Number of pages	3
Journal	Journal of Organic Chemistry
Volume	53
Issue number	16
DOIs	https://doi.org/10.1021/jo00251a054
State	Published - Aug 1 1988

All Science Journal Classification (ASJC) codes

Organic Chemistry

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title = "Enzymic Regioselectivity in the Hydroxylation of Cholesterol Catalyzed by a Membrane-Spanning Metalloporphyrin",

abstract = "The hydroxylation of simple alkanes and the selective C-25 hydroxylation of cholesterol have been achieved with a membrane-spanning Mn(III) porphyrin positioned in a synthetic bilayer assembly by appended steroidal substituents.",

author = "Groves, {John Taylor} and Ronny Neumann",

year = "1988",

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journal = "Journal of Organic Chemistry",

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AU - Groves, John Taylor

AU - Neumann, Ronny

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Y1 - 1988/8/1

N2 - The hydroxylation of simple alkanes and the selective C-25 hydroxylation of cholesterol have been achieved with a membrane-spanning Mn(III) porphyrin positioned in a synthetic bilayer assembly by appended steroidal substituents.

AB - The hydroxylation of simple alkanes and the selective C-25 hydroxylation of cholesterol have been achieved with a membrane-spanning Mn(III) porphyrin positioned in a synthetic bilayer assembly by appended steroidal substituents.

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JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

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Enzymic Regioselectivity in the Hydroxylation of Cholesterol Catalyzed by a Membrane-Spanning Metalloporphyrin

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