A practical, chemoenzymatic, four-step synthesis of the LTD4 antagonist MK-0679 is described. The key steps are enzymatic hydrolysis of the prochiral diester to the ester-acid in 99% enantiomeric excess followed by aluminum mediated amidation of the methyl ester to afford MK-0679 in high overall yield. This synthesis is superior to the synthesis of the racemate MK-0571.
|Original language||English (US)|
|Number of pages||6|
|Journal||Pure and Applied Chemistry|
|State||Published - Jan 1 1992|
All Science Journal Classification (ASJC) codes
- Chemical Engineering(all)