EnvZ functions through OmpR to control porin gene expression in Escherichia coli K-12

J. M. Slauch, S. Garrett, D. E. Jackson, T. J. Silhavy

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

The regulatory proteins OmpR and EnvZ are both required to activate expression of the genes for the major outer membrane porin proteins, OmpF and OmpC, of Escherichia coli K-12. Here we show that OmpR, under certain conditions, could activate porin expression in the complete absence of EnvZ. In addition, the pleiotropic phenotypes conferred by a particular envZ mutation (envZ473) required the presence of functional OmpR protein. These results lead us to conclude that EnvZ and OmpR act in sequential fashion to activate porin gene expression; i.e., EnvZ modifies or in some way directs OmpR, which in turn acts at the appropriate porin gene promoter.

Original languageEnglish (US)
Pages (from-to)439-441
Number of pages3
JournalJournal of bacteriology
Volume170
Issue number1
DOIs
StatePublished - 1988

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Molecular Biology

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