TY - JOUR
T1 - Enhanced Intersubject Correlations during Movie Viewing Correlate with Successful Episodic Encoding
AU - Hasson, Uri
AU - Furman, Orit
AU - Clark, Dav
AU - Dudai, Yadin
AU - Davachi, Lila
N1 - Funding Information:
This work was supported by The NYU-Weizmann Institute Collaborative Fund in the Neurosciences (to L.D. and Y.D.), The Seaver Foundation (to L.D.), and a HFSP long-term fellowship (to U.H.). We would like to thank K. Ochsner, D. Heeger, and R. Malach for helpful comments and suggestions. Part of the work on this manuscript was conducted while Y.D. visited NYU as the Albert and Blanche Willner Family Global Distinguished Professor of Neuroscience at the Center for Neural Science.
PY - 2008/2/7
Y1 - 2008/2/7
N2 - While much has been learned regarding the neural substrates supporting episodic encoding using highly controlled experimental protocols, relatively little is known regarding the neural bases of episodic encoding of real-world events. In an effort to examine this issue, we measured fMRI activity while observers viewed a novel TV sitcom. Three weeks later, subsequent memory (SM) for the narrative content of movie events was assessed. We analyzed the encoding data for intersubject correlations (ISC) based on subjects' subsequent memory (ISC-SM) performance to identify brain regions whose BOLD response is significantly more correlated across subjects during portions of the movie that are successfully as compared to unsuccessfully encoded. These regions include the parahippocampal gyrus, superior temporal gyrus, anterior temporal poles, and the temporal-parietal junction. Further analyses reveal (1) that these correlated regions can display distinct activation profiles and (2) that the results seen with the ISC-SM analysis are complementary to more traditional linear models and allow analysis of complex time course data. Thus, the ISC-SM analysis extends traditional subsequent memory findings to a rich, dynamic and more ecologically valid situation.
AB - While much has been learned regarding the neural substrates supporting episodic encoding using highly controlled experimental protocols, relatively little is known regarding the neural bases of episodic encoding of real-world events. In an effort to examine this issue, we measured fMRI activity while observers viewed a novel TV sitcom. Three weeks later, subsequent memory (SM) for the narrative content of movie events was assessed. We analyzed the encoding data for intersubject correlations (ISC) based on subjects' subsequent memory (ISC-SM) performance to identify brain regions whose BOLD response is significantly more correlated across subjects during portions of the movie that are successfully as compared to unsuccessfully encoded. These regions include the parahippocampal gyrus, superior temporal gyrus, anterior temporal poles, and the temporal-parietal junction. Further analyses reveal (1) that these correlated regions can display distinct activation profiles and (2) that the results seen with the ISC-SM analysis are complementary to more traditional linear models and allow analysis of complex time course data. Thus, the ISC-SM analysis extends traditional subsequent memory findings to a rich, dynamic and more ecologically valid situation.
KW - SYSNEURO
UR - http://www.scopus.com/inward/record.url?scp=37549010543&partnerID=8YFLogxK
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U2 - 10.1016/j.neuron.2007.12.009
DO - 10.1016/j.neuron.2007.12.009
M3 - Article
C2 - 18255037
AN - SCOPUS:37549010543
SN - 0896-6273
VL - 57
SP - 452
EP - 462
JO - Neuron
JF - Neuron
IS - 3
ER -