TY - JOUR
T1 - Enhanced dissolution of inhalable cyclosporine nano-matrix particles with mannitol as matrix former
AU - Yamasaki, Keishi
AU - Kwok, Philip Chi Lip
AU - Fukushige, Kaori
AU - Prud'Homme, Robert K.
AU - Chan, Hak Kim
N1 - Funding Information:
This work was financially supported by the Australian Research Council (Discovery Project 0985367).
Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2011/11/25
Y1 - 2011/11/25
N2 - This study aims to improve the dissolution of inhalable cyclosporine A nanoparticles by formulating the drug with mannitol as a hydrophilic nano-matrix former. The effect of mannitol content on the aerosol performance of the nano-matrix particles was also examined. Cyclosporine A nanosuspensions were produced by anti-solvent precipitation using a multi-inlet vortex mixer. Various amounts of mannitol were dissolved into the suspensions before spray drying to obtain micron-sized aggregates (nano-matrix powders). Dissolution properties of the powders in an aqueous medium, with the drug content, aggregate size distribution, surface roughness, physicochemical properties and aerosol performance were determined. The powders contained amorphous cyclosporine A and α-crystalline mannitol, with drug content being very close to the theoretical doses. Inclusion of mannitol enhanced the dissolution rate of the drug, without significantly affecting the aggregate size distribution, surface roughness and aerosol performance. This formulation approach may be applicable to improving the dissolution rate and bioavailability of hydrophobic drugs.
AB - This study aims to improve the dissolution of inhalable cyclosporine A nanoparticles by formulating the drug with mannitol as a hydrophilic nano-matrix former. The effect of mannitol content on the aerosol performance of the nano-matrix particles was also examined. Cyclosporine A nanosuspensions were produced by anti-solvent precipitation using a multi-inlet vortex mixer. Various amounts of mannitol were dissolved into the suspensions before spray drying to obtain micron-sized aggregates (nano-matrix powders). Dissolution properties of the powders in an aqueous medium, with the drug content, aggregate size distribution, surface roughness, physicochemical properties and aerosol performance were determined. The powders contained amorphous cyclosporine A and α-crystalline mannitol, with drug content being very close to the theoretical doses. Inclusion of mannitol enhanced the dissolution rate of the drug, without significantly affecting the aggregate size distribution, surface roughness and aerosol performance. This formulation approach may be applicable to improving the dissolution rate and bioavailability of hydrophobic drugs.
KW - Cyclosporine A
KW - Dissolution
KW - Dry powder aerosol
KW - Mannitol
KW - Nanoparticles
KW - Pulmonary drug delivery
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U2 - 10.1016/j.ijpharm.2011.08.010
DO - 10.1016/j.ijpharm.2011.08.010
M3 - Article
C2 - 21864662
AN - SCOPUS:80054697360
SN - 0378-5173
VL - 420
SP - 34
EP - 42
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
IS - 1
ER -