Engineered chimeric receptors for dissecting interferon signaling

Aaron E. Lin; Emily V. Mesev; Jared E. Toettcher; Alexander Ploss

doi:10.1128/jvi.01680-23

Engineered chimeric receptors for dissecting interferon signaling

Aaron E. Lin, Emily V. Mesev, Jared E. Toettcher, Alexander Ploss

Research output: Contribution to journal › Article › peer-review

Abstract

Though interferons (IFNs) were once heralded as panaceas to numerous diseases, how cells decode varying IFN stimuli and subsequently produce (in)appropriate signaling remain unclear. Our labs recently engineered novel erythropoietin receptor-IFN chimeric receptors, and we highlight their utility in two cases uncovering differentialgenetic determinants of type I (IFN-α/β) and type III (IFN-λ) IFN signaling. These and other types of synthetic (cytokine) receptors could be expanded to real-time signaling dynamics and in vivo studies.

Original language	English (US)
Article number	e01680-23
Journal	Journal of virology
Volume	98
Issue number	10
DOIs	https://doi.org/10.1128/jvi.01680-23
State	Published - Oct 2024

All Science Journal Classification (ASJC) codes

Microbiology
Immunology
Insect Science
Virology

Keywords

STAT signaling
flavivirus,innate immunity
interferons
virus-host interactions

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10.1128/jvi.01680-23

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title = "Engineered chimeric receptors for dissecting interferon signaling",

abstract = "Though interferons (IFNs) were once heralded as panaceas to numerous diseases, how cells decode varying IFN stimuli and subsequently produce (in)appropriate signaling remain unclear. Our labs recently engineered novel erythropoietin receptor-IFN chimeric receptors, and we highlight their utility in two cases uncovering differentialgenetic determinants of type I (IFN-α/β) and type III (IFN-λ) IFN signaling. These and other types of synthetic (cytokine) receptors could be expanded to real-time signaling dynamics and in vivo studies.",

keywords = "STAT signaling, flavivirus,innate immunity, interferons, virus-host interactions",

author = "Lin, {Aaron E.} and Mesev, {Emily V.} and Toettcher, {Jared E.} and Alexander Ploss",

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AU - Mesev, Emily V.

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AU - Ploss, Alexander

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AB - Though interferons (IFNs) were once heralded as panaceas to numerous diseases, how cells decode varying IFN stimuli and subsequently produce (in)appropriate signaling remain unclear. Our labs recently engineered novel erythropoietin receptor-IFN chimeric receptors, and we highlight their utility in two cases uncovering differentialgenetic determinants of type I (IFN-α/β) and type III (IFN-λ) IFN signaling. These and other types of synthetic (cytokine) receptors could be expanded to real-time signaling dynamics and in vivo studies.

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KW - flavivirus,innate immunity

KW - interferons

KW - virus-host interactions

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ER -

Engineered chimeric receptors for dissecting interferon signaling

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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