Enantioselective Synthesis of 1,3-Dioxygen-substituted Chiral Building Blocks

Chris H. Senanayake, Robert D. Larsen, Timothy J. Bill, Ji Liu, Edward G. Corley, Paul J. Reider

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


The extremely useful chiral building blocks 3-hydroxy-2-alkylpropionates 8 are prepared in either S or R eantiomeric form via the diastereoselective addition of chiral alcohols to arylketenes 4 and the manipulation of the resultant chiral 2-arylaliphatic esters 5 and 6. Application of this methodology to the asymmetric syntheses of 3-mercapto-2-alkylpropionates (9) and (S)-(-)-paraconic acid (3) is described.

Original languageEnglish (US)
Pages (from-to)199-200
Number of pages2
Issue number3
StatePublished - Mar 1 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Organic Chemistry


Dive into the research topics of 'Enantioselective Synthesis of 1,3-Dioxygen-substituted Chiral Building Blocks'. Together they form a unique fingerprint.

Cite this