TY - JOUR
T1 - Enantioselective organocatalytic transfer hydrogenation reactions using Hantzsch esters
AU - Ouellet, Stéphane G.
AU - Walji, Abbas M.
AU - Macmillan, David W.C.
PY - 2007/12
Y1 - 2007/12
N2 - Within the realm of catalytic asymmetric hydrogenation, the focus continues to be on the use of chiral metal complexes in conjunction with a hydrogen source. Recently, the widespread development of organocatalysis, including the invention of iminium activation, has led to the discovery of many new enantioselective transformations. Based on this strategy, a number of bioinspired processes for the enantioselective organocatalytic transfer hydrogenation of α,β-unsaturated carbonyl compounds and imines have been discovered. These topics will be the focus of this Account.
AB - Within the realm of catalytic asymmetric hydrogenation, the focus continues to be on the use of chiral metal complexes in conjunction with a hydrogen source. Recently, the widespread development of organocatalysis, including the invention of iminium activation, has led to the discovery of many new enantioselective transformations. Based on this strategy, a number of bioinspired processes for the enantioselective organocatalytic transfer hydrogenation of α,β-unsaturated carbonyl compounds and imines have been discovered. These topics will be the focus of this Account.
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U2 - 10.1021/ar7001864
DO - 10.1021/ar7001864
M3 - Review article
C2 - 18085748
AN - SCOPUS:38049089797
SN - 0001-4842
VL - 40
SP - 1327
EP - 1339
JO - Accounts of chemical research
JF - Accounts of chemical research
IS - 12
ER -