Enantioselective organocatalytic transfer hydrogenation reactions using Hantzsch esters

Stéphane G. Ouellet, Abbas M. Walji, David W.C. Macmillan

Research output: Contribution to journalReview article

392 Scopus citations

Abstract

Within the realm of catalytic asymmetric hydrogenation, the focus continues to be on the use of chiral metal complexes in conjunction with a hydrogen source. Recently, the widespread development of organocatalysis, including the invention of iminium activation, has led to the discovery of many new enantioselective transformations. Based on this strategy, a number of bioinspired processes for the enantioselective organocatalytic transfer hydrogenation of α,β-unsaturated carbonyl compounds and imines have been discovered. These topics will be the focus of this Account.

Original languageEnglish (US)
Pages (from-to)1327-1339
Number of pages13
JournalAccounts of chemical research
Volume40
Issue number12
DOIs
StatePublished - Dec 2007

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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