An asymmetric proline catalyzed aldol reaction with α-thioacetal aldehydes has been developed. Thioacetal bearing aldehydes readily participate as electrophilic cross-aldol partners with a broad range of aldehyde and ketone donors. High levels of reaction efficiency as well as diastereo- and enantiocontrol are observed in the production of anti-aldol adducts.
|Original language||English (US)|
|Number of pages||10|
|State||Published - Aug 23 2004|
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry