Enantioselective, nickel-catalyzed suzuki cross-coupling of quinolinium ions

Jason D. Shields, Derek T. Ahneman, Thomas J.A. Graham, Abigail G. Doyle

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


Quinolinium ions are engaged in an asymmetric, Ni-catalyzed Suzuki cross-coupling to yield 2-aryl- and 2-heteroaryl-1,2-dihydroquinolines. Key to the development of this method is the use of a Ni(II) precatalyst that activates without the need for strong reductants or high temperatures. The Ni-iminium activation mode is demonstrated as an exceptionally mild pathway to generate enantioenriched products from racemic starting materials.

Original languageEnglish (US)
Pages (from-to)142-145
Number of pages4
JournalOrganic letters
Issue number1
StatePublished - Jan 3 2014

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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