Enantioselective linchpin catalysis by SOMO catalysis: An approach to the asymmetric a-chlorination of aldehydes and terminal epoxide formation

Muriel Amatore, Teresa D. Beeson, Sean P. Brown, David W.C. MacMillan

Research output: Contribution to journalArticlepeer-review

146 Scopus citations

Abstract

Time for SOme MOre: For the first time SOMO (singly occupied molecular orbital) activation has been exploited to allow a new approach to the α-chlorination of aldehydes. This transformation can be readily implemented as part of a linchpin catalysis approach to the enantioselective production of terminal epoxides.

Original languageEnglish (US)
Pages (from-to)5121-5124
Number of pages4
JournalAngewandte Chemie - International Edition
Volume48
Issue number28
DOIs
StatePublished - Jun 29 2009

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Keywords

  • Enantioselectivity asymmetric catalysis
  • Epoxidation -
  • Organocatalysis

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