Enantioselective Decarboxylative Arylation of α-Amino Acids via the Merger of Photoredox and Nickel Catalysis

Zhiwei Zuo, Huan Cong, Wei Li, Junwon Choi, Gregory C. Fu, David W.C. MacMillan

Research output: Contribution to journalArticle

238 Scopus citations

Abstract

An asymmetric decarboxylative Csp3-Csp2 cross-coupling has been achieved via the synergistic merger of photoredox and nickel catalysis. This mild, operationally simple protocol transforms a wide variety of naturally abundant α-amino acids and readily available aryl halides into valuable chiral benzylic amines in high enantiomeric excess, thereby producing motifs found in pharmacologically active agents.

Original languageEnglish (US)
Pages (from-to)1832-1835
Number of pages4
JournalJournal of the American Chemical Society
Volume138
Issue number6
DOIs
StatePublished - Feb 17 2016

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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