Abstract
An asymmetric decarboxylative Csp3-Csp2 cross-coupling has been achieved via the synergistic merger of photoredox and nickel catalysis. This mild, operationally simple protocol transforms a wide variety of naturally abundant α-amino acids and readily available aryl halides into valuable chiral benzylic amines in high enantiomeric excess, thereby producing motifs found in pharmacologically active agents.
Original language | English (US) |
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Pages (from-to) | 1832-1835 |
Number of pages | 4 |
Journal | Journal of the American Chemical Society |
Volume | 138 |
Issue number | 6 |
DOIs | |
State | Published - Feb 17 2016 |
All Science Journal Classification (ASJC) codes
- Chemistry(all)
- Biochemistry
- Catalysis
- Colloid and Surface Chemistry