Enantioselective copper-catalyzed construction of aryl pyrroloindolines via an arylation-cyclization cascade

Shaolin Zhu; David W.C. MacMillan

doi:10.1021/ja305100g

Enantioselective copper-catalyzed construction of aryl pyrroloindolines via an arylation-cyclization cascade

Shaolin Zhu, David W.C. MacMillan

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253 Scopus citations

Abstract

An enantioselective arylation-cyclization cascade has been accomplished using a combination of diaryliodonium salts and asymmetric copper catalysis. These mild catalytic conditions provide a new strategy for the enantioselective construction of pyrroloindolines, an important alkaloid structural motif that is commonly found among biologically active natural products.

Original language	English (US)
Pages (from-to)	10815-10818
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	134
Issue number	26
DOIs	https://doi.org/10.1021/ja305100g
State	Published - Jul 4 2012

All Science Journal Classification (ASJC) codes

General Chemistry
Biochemistry
Catalysis
Colloid and Surface Chemistry

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10.1021/ja305100g

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abstract = "An enantioselective arylation-cyclization cascade has been accomplished using a combination of diaryliodonium salts and asymmetric copper catalysis. These mild catalytic conditions provide a new strategy for the enantioselective construction of pyrroloindolines, an important alkaloid structural motif that is commonly found among biologically active natural products.",

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N2 - An enantioselective arylation-cyclization cascade has been accomplished using a combination of diaryliodonium salts and asymmetric copper catalysis. These mild catalytic conditions provide a new strategy for the enantioselective construction of pyrroloindolines, an important alkaloid structural motif that is commonly found among biologically active natural products.

AB - An enantioselective arylation-cyclization cascade has been accomplished using a combination of diaryliodonium salts and asymmetric copper catalysis. These mild catalytic conditions provide a new strategy for the enantioselective construction of pyrroloindolines, an important alkaloid structural motif that is commonly found among biologically active natural products.

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Enantioselective copper-catalyzed construction of aryl pyrroloindolines via an arylation-cyclization cascade

Abstract

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