Abstract
Straighten out the mixture: A dynamic mixture of acyclic isomers of tributyltin enolates undergoes a {Cr(salen)}-catalyzed alkylation reaction to generate methyl ketones that contain α-carbonyl quaternary stereocenters in high yield and enantioselectivity (salen = N,N′-bis(salicylidene) ethylenediamine dianion). A mechanism is proposed which involves halide activation by a cationic metal complex. (Chemical Equation Presented).
Original language | English (US) |
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Pages (from-to) | 3701-3705 |
Number of pages | 5 |
Journal | Angewandte Chemie - International Edition |
Volume | 46 |
Issue number | 20 |
DOIs | |
State | Published - 2007 |
All Science Journal Classification (ASJC) codes
- General Chemistry
- Catalysis
Keywords
- Alkylation
- Asymmetric catalysis
- Chromium
- Enolates
- N,O ligands