Enantioselective α-trifluoromethylation of aldehydes via photoredox organocatalysis

David A. Nagib, Mark E. Scott, David W.C. MacMillan

Research output: Contribution to journalArticle

737 Scopus citations

Abstract

(Chemical Equation Presented) The first enantioselective, organocatalytic α-trifluoromethylation and α-perfluoroalkylation of aldehydes have been accomplished using a readily available iridium photocatalyst and a chiral imidazolidinone catalyst. A range of α-trifluoromethyl and α-perfluoroalkyl aldehydes were obtained from commercially available perfluoroalkyl halides with high efficiency and enantioselectivity. The resulting α-trifluoromethyl aldehydes were subsequently shown to be versatile precursors for the construction of a variety of enantioenriched trifluoromethylated building blocks.

Original languageEnglish (US)
Pages (from-to)10875-10877
Number of pages3
JournalJournal of the American Chemical Society
Volume131
Issue number31
DOIs
StatePublished - Aug 12 2009

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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