Enantioselective α-arylation of carbonyls via Cu(I)-bisoxazoline catalysis

James S. Harvey, Scott P. Simonovich, Christopher R. Jamison, David W.C. MacMillan

Research output: Contribution to journalArticlepeer-review

165 Scopus citations


The enantioselective α-arylation of both lactones and acyl oxazolidones has been accomplished using a combination of diaryliodonium salts and copper catalysis. These mild catalytic conditions provide a new strategy for the enantioselective construction and retention of enolizable α-carbonyl benzylic stereocenters, a valuable synthon for the production of medicinal agents.

Original languageEnglish (US)
Pages (from-to)13782-13785
Number of pages4
JournalJournal of the American Chemical Society
Issue number35
StatePublished - Sep 7 2011

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • Biochemistry
  • Catalysis
  • Colloid and Surface Chemistry


Dive into the research topics of 'Enantioselective α-arylation of carbonyls via Cu(I)-bisoxazoline catalysis'. Together they form a unique fingerprint.

Cite this