Enantioselective α-arylation of carbonyls via Cu(I)-bisoxazoline catalysis

James S. Harvey, Scott P. Simonovich, Christopher R. Jamison, David W.C. MacMillan

Research output: Contribution to journalArticle

134 Scopus citations

Abstract

The enantioselective α-arylation of both lactones and acyl oxazolidones has been accomplished using a combination of diaryliodonium salts and copper catalysis. These mild catalytic conditions provide a new strategy for the enantioselective construction and retention of enolizable α-carbonyl benzylic stereocenters, a valuable synthon for the production of medicinal agents.

Original languageEnglish (US)
Pages (from-to)13782-13785
Number of pages4
JournalJournal of the American Chemical Society
Volume133
Issue number35
DOIs
StatePublished - Sep 7 2011

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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