Enantioselective α-alkenylation of aldehydes with boronic acids via the synergistic combination of copper(II) and amine catalysis

Jason M. Stevens, David W.C. MacMillan

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

The enantioselective α-alkenylation of aldehydes has been accomplished using boronic acids via the synergistic combination of copper and chiral amine catalysis. The merger of two highly utilized and robust catalytic systems has allowed for the development of a mild and operationally trivial protocol for the direct formation of α-formyl olefins employing common building blocks for organic synthesis.

Original languageEnglish (US)
Pages (from-to)11756-11759
Number of pages4
JournalJournal of the American Chemical Society
Volume135
Issue number32
DOIs
StatePublished - Aug 14 2013

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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