Emerging strategies for treating metastasis

Mark Esposito, Shridar Ganesan, Yibin Kang

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

The systemic spread of tumor cells is the ultimate cause of the majority of deaths from cancer, yet few successful therapeutic strategies have emerged to specifically target metastasis. Here we discuss recent advances in our understanding of tumor-intrinsic pathways driving metastatic colonization and therapeutic resistance, as well as immune-activating strategies to target metastatic disease. We focus on therapeutically exploitable mechanisms, promising strategies in preclinical and clinical development, and emerging areas with potential to become innovative treatments.

Original languageEnglish (US)
Pages (from-to)258-270
Number of pages13
JournalNature Cancer
Volume2
Issue number3
DOIs
StatePublished - Mar 2021

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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