Emerging strategies for expanding the toolbox of enzymes in biocatalysis

Braddock A. Sandoval, Todd K. Hyster

Research output: Contribution to journalReview articlepeer-review

87 Scopus citations


Expanding the repertoire of reactions available to enzymes is an enduring challenge in biocatalysis. Owing to the synthetic versatility of transition metals, metalloenzymes have been favored targets for achieving new catalytic functions. Although less well explored, enzymes lacking metal centers can also be effective catalysts for non-natural reactions, providing access to reaction modalities that compliment those available to metals. By understanding how these activation modes can reveal new functions, strategies can be developed to access novel biocatalytic reactions. This review will cover discoveries in the last two years which access catalytic reactions that go beyond the native repertoire of metal-free biocatalysts.

Original languageEnglish (US)
Pages (from-to)45-51
Number of pages7
JournalCurrent Opinion in Chemical Biology
StatePublished - Apr 2020

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry


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