Elevated emdogenous serum macropkage colony-stimulating factor in the early stage of fungemia following bone marrow transplantation

W. P. Petros, Joshua D. Rabinowitz, A. R. Stuart, C. Gupton, E. M. Alderman, W. P. Peters

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Murine studies have reported elevated serum macrophage colony-stimulating factor (M-CSF) concentrations in animals inoculated with fungus; however, the human cytokine response to fungemia has not been described. Endogenous M-CSF serum concentrations were measured in 18 autologous bone marrow transplant patients with positive blood fungal cultures. Seventeen of the 18 patients received the same high-dose chemotherapy regimen with autologous hematopoietic support. M-CSF concentrations were determined in serum samples obtained 1 week before and within 2 days of the first positive blood culture. Serum M-CSF rose more than three-fold in a majority of patients at the time of positive culture in contrast to concentrations obtained in the previous week (medians 11.1 and 2.8 ng/mL, respectively; p=0.001). Median values at the time of positive blood culture were also significantly higher than those obtained in a matched control group of patients without positive blood cultures (n=18; median 2.60 ng/mL; p=0.001). These data demonstrate that endogenous serum M-CSF is elevated in the early stages of human systemic fungal infection and thus may have important diagnostic and therapeutic implications.

Original languageEnglish (US)
Pages (from-to)582-586
Number of pages5
JournalExperimental Hematology
Volume22
Issue number7
StatePublished - Jan 1 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Hematology
  • Genetics
  • Cell Biology
  • Cancer Research

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