Elevated emdogenous serum macropkage colony-stimulating factor in the early stage of fungemia following bone marrow transplantation

W. P. Petros, J. Rabinowitz, A. R. Stuart, C. Gupton, E. M. Alderman, W. P. Peters

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Murine studies have reported elevated serum macrophage colony-stimulating factor (M-CSF) concentrations in animals inoculated with fungus; however, the human cytokine response to fungemia has not been described. Endogenous M-CSF serum concentrations were measured in 18 autologous bone marrow transplant patients with positive blood fungal cultures. Seventeen of the 18 patients received the same high-dose chemotherapy regimen with autologous hematopoietic support. M-CSF concentrations were determined in serum samples obtained 1 week before and within 2 days of the first positive blood culture. Serum M-CSF rose more than three-fold in a majority of patients at the time of positive culture in contrast to concentrations obtained in the previous week (medians 11.1 and 2.8 ng/mL, respectively; p=0.001). Median values at the time of positive blood culture were also significantly higher than those obtained in a matched control group of patients without positive blood cultures (n=18; median 2.60 ng/mL; p=0.001). These data demonstrate that endogenous serum M-CSF is elevated in the early stages of human systemic fungal infection and thus may have important diagnostic and therapeutic implications.

Original languageEnglish (US)
Pages (from-to)582-586
Number of pages5
JournalExperimental Hematology
Volume22
Issue number7
StatePublished - 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Hematology
  • Genetics
  • Cell Biology
  • Cancer Research

Keywords

  • Fungemia
  • M-CSF
  • Transplantation

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