Electrophysiological Low-Frequency Coherence and Cross-Frequency Coupling Contribute to BOLD Connectivity

Liang Wang, Yuri B. Saalmann, Mark A. Pinsk, Michael J. Arcaro, Sabine Kastner

Research output: Contribution to journalArticle

95 Scopus citations

Abstract

Brain networks are commonly defined using correlations between blood oxygen level-dependent (BOLD) signals in different brain areas. Although evidence suggests that gamma-band (30-100 Hz) neural activity contributes to local BOLD signals, the neural basis of interareal BOLD correlations is unclear. We first defined a visual network in monkeys based on converging evidence from interareal BOLD correlations during a fixation task, task-free state, and anesthesia, and then simultaneously recorded local field potentials (LFPs) from the same four network areas in the task-free state. Low-frequency oscillations (<20 Hz), and not gamma activity, predominantly contributed to interareal BOLD correlations. The low-frequency oscillations also influenced local processing by modulating gamma activity within individual areas. We suggest that such cross-frequency coupling links local BOLD signals to BOLD correlations across distributed networks.

Original languageEnglish (US)
Pages (from-to)1010-1020
Number of pages11
JournalNeuron
Volume76
Issue number5
DOIs
StatePublished - Dec 6 2012

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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