Elba, a novel developmentally regulated chromatin boundary factor is a hetero-tripartite DNA binding complex

Tsutomu Aoki, Ali Sarkeshik, John Yates, Paul Schedl

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Chromatin boundaries subdivide eukaryotic chromosomes into functionally autonomous domains of genetic activity. This subdivision insulates genes and/or regulatory elements within a domain from promiscuous interactions with nearby domains. While it was previously assumed that the chromosomal domain landscape is fixed, there is now growing evidence that the landscape may be subject to tissue and stage specific regulation. Here we report the isolation and characterization of a novel developmentally restricted boundary factor, Elba. We show that Elba is an unusual hetero-tripartite protein complex that requires all three proteins for DNA binding and insulator activity.

Original languageEnglish (US)
Article numbere00171
JournaleLife
Volume2012
Issue number1
DOIs
StatePublished - Dec 13 2012

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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