EGL-17(FGF) expression coordinates the attraction of the migrating sex myoblasts with vulval induction in C. elegans

Rebecca D. Burdine, Catherine S. Branda, Michael J. Stern

Research output: Contribution to journalArticle

154 Scopus citations

Abstract

During the development of the egg-laying system in Caenorhabditis elegans hermaphrodites, central gonadal cells organize the alignment of the vulva with the sex myoblasts, the progenitors of the egg-laying muscles. A fibroblast growth factor [EGL-17(FGF)] and an FGF receptor [EGL-15(FGFR)] are involved in the gonadal signals that guide the migrations of the sex myoblasts. Here we show that EGL-17(FGF) can act as an instructive guidance cue to direct the sex myoblasts to their final destinations. We find that egl-17 reporter constructs are expressed in the primary vulval cell and that EGL-17(FGF) expression in this cell correlates with the precise positioning of the sex myoblasts. We postulate that EGL-17(FGF) helps to coordinate the development of a functional egg-laying system, linking vulval induction with proper sex myoblast migration.

Original languageEnglish (US)
Pages (from-to)1083-1093
Number of pages11
JournalDevelopment
Volume125
Issue number6
StatePublished - Apr 28 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology

Keywords

  • Caenorhabditis
  • Cell migration
  • EGL-17
  • FGF
  • Sex myoblasts
  • Vulval induction

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