The convergent synthesis of a potent α1A-selective adrenoceptor antagonist is described. Salient features of the synthesis include the enzymatic resolution of a racemic dihydropyrimidinone and the use of a palladium coupling reaction in the synthesis of 2,4′-dipyridyl.
All Science Journal Classification (ASJC) codes
- Organic Chemistry
- Enzymatic resolution
- Palladium coupling