Efficient synthesis of the optically active dihydropyrimidinone of a potent α1A-selective adrenoceptor antagonist

Daniel R. Sidler, Nancy Barta, Wenjie Li, Essa Hu, Louis Matty, Nori Ikemoto, Jeffrey S. Campbell, Michel Chartrain, Kozo Gbewonyo, Russell Boyd, Edward G. Corley, Richard G. Ball, Robert D. Larsen, Paul J. Reider

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

The convergent synthesis of a potent α1A-selective adrenoceptor antagonist is described. Salient features of the synthesis include the enzymatic resolution of a racemic dihydropyrimidinone and the use of a palladium coupling reaction in the synthesis of 2,4′-dipyridyl.

Original languageEnglish (US)
Pages (from-to)646-652
Number of pages7
JournalCanadian Journal of Chemistry
Volume80
Issue number6
DOIs
StatePublished - Sep 18 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Organic Chemistry

Keywords

  • Dihydropyrimidinone
  • Enzymatic resolution
  • Palladium coupling

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    Sidler, D. R., Barta, N., Li, W., Hu, E., Matty, L., Ikemoto, N., Campbell, J. S., Chartrain, M., Gbewonyo, K., Boyd, R., Corley, E. G., Ball, R. G., Larsen, R. D., & Reider, P. J. (2002). Efficient synthesis of the optically active dihydropyrimidinone of a potent α1A-selective adrenoceptor antagonist. Canadian Journal of Chemistry, 80(6), 646-652. https://doi.org/10.1139/v02-079