Efficient synthesis of the optically active dihydropyrimidinone of a potent α1A-selective adrenoceptor antagonist

Daniel R. Sidler; Nancy Barta; Wenjie Li; Essa Hu; Louis Matty; Nori Ikemoto; Jeffrey S. Campbell; Michel Chartrain; Kozo Gbewonyo; Russell Boyd; Edward G. Corley; Richard G. Ball; Robert D. Larsen; Paul J. Reider

doi:10.1139/v02-079

Efficient synthesis of the optically active dihydropyrimidinone of a potent α_1A-selective adrenoceptor antagonist

Daniel R. Sidler, Nancy Barta, Wenjie Li, Essa Hu, Louis Matty, Nori Ikemoto, Jeffrey S. Campbell, Michel Chartrain, Kozo Gbewonyo, Russell Boyd, Edward G. Corley, Richard G. Ball, Robert D. Larsen, Paul J. Reider

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

The convergent synthesis of a potent α_1A-selective adrenoceptor antagonist is described. Salient features of the synthesis include the enzymatic resolution of a racemic dihydropyrimidinone and the use of a palladium coupling reaction in the synthesis of 2,4′-dipyridyl.

Original language	English (US)
Pages (from-to)	646-652
Number of pages	7
Journal	Canadian Journal of Chemistry
Volume	80
Issue number	6
DOIs	https://doi.org/10.1139/v02-079
State	Published - 2002
Externally published	Yes

All Science Journal Classification (ASJC) codes

Catalysis
General Chemistry
Organic Chemistry

Keywords

Dihydropyrimidinone
Enzymatic resolution
Palladium coupling

Access to Document

10.1139/v02-079

Cite this

Sidler, D. R., Barta, N., Li, W., Hu, E., Matty, L., Ikemoto, N., Campbell, J. S., Chartrain, M., Gbewonyo, K., Boyd, R., Corley, E. G., Ball, R. G., Larsen, R. D., & Reider, P. J. (2002). Efficient synthesis of the optically active dihydropyrimidinone of a potent α_1A-selective adrenoceptor antagonist. Canadian Journal of Chemistry, 80(6), 646-652. https://doi.org/10.1139/v02-079

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author = "Sidler, {Daniel R.} and Nancy Barta and Wenjie Li and Essa Hu and Louis Matty and Nori Ikemoto and Campbell, {Jeffrey S.} and Michel Chartrain and Kozo Gbewonyo and Russell Boyd and Corley, {Edward G.} and Ball, {Richard G.} and Larsen, {Robert D.} and Reider, {Paul J.}",

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language = "English (US)",

volume = "80",

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T1 - Efficient synthesis of the optically active dihydropyrimidinone of a potent α1A-selective adrenoceptor antagonist

AU - Sidler, Daniel R.

AU - Barta, Nancy

AU - Li, Wenjie

AU - Hu, Essa

AU - Matty, Louis

AU - Ikemoto, Nori

AU - Campbell, Jeffrey S.

AU - Chartrain, Michel

AU - Gbewonyo, Kozo

AU - Boyd, Russell

AU - Corley, Edward G.

AU - Ball, Richard G.

AU - Larsen, Robert D.

AU - Reider, Paul J.

PY - 2002

Y1 - 2002

N2 - The convergent synthesis of a potent α1A-selective adrenoceptor antagonist is described. Salient features of the synthesis include the enzymatic resolution of a racemic dihydropyrimidinone and the use of a palladium coupling reaction in the synthesis of 2,4′-dipyridyl.

AB - The convergent synthesis of a potent α1A-selective adrenoceptor antagonist is described. Salient features of the synthesis include the enzymatic resolution of a racemic dihydropyrimidinone and the use of a palladium coupling reaction in the synthesis of 2,4′-dipyridyl.

KW - Dihydropyrimidinone

KW - Enzymatic resolution

KW - Palladium coupling

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