Efficient synthesis of N-arylpiperazinones via a selective intramolecular Mitsunobu cyclodehydration

Steven A. Weissman; Stephanie Lewis; David Askin; R. P. Volante; Paul J. Reider

doi:10.1016/S0040-4039(98)01670-0

Efficient synthesis of N-arylpiperazinones via a selective intramolecular Mitsunobu cyclodehydration

Steven A. Weissman, Stephanie Lewis, David Askin, R. P. Volante, Paul J. Reider

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

A practical two pot synthesis of N-arylpiperazinones from the corresponding aniline is described. The key transformation is a selective intramolecular Mitsunobu cyclodehydration of an amidoalcohol intermediate. A series of N-arylpiperazinones were prepared in yields up to 89%.

Original language	English (US)
Pages (from-to)	7459-7462
Number of pages	4
Journal	Tetrahedron Letters
Volume	39
Issue number	41
DOIs	https://doi.org/10.1016/S0040-4039(98)01670-0
State	Published - Oct 8 1998
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(98)01670-0

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title = "Efficient synthesis of N-arylpiperazinones via a selective intramolecular Mitsunobu cyclodehydration",

abstract = "A practical two pot synthesis of N-arylpiperazinones from the corresponding aniline is described. The key transformation is a selective intramolecular Mitsunobu cyclodehydration of an amidoalcohol intermediate. A series of N-arylpiperazinones were prepared in yields up to 89\%.",

author = "Weissman, \{Steven A.\} and Stephanie Lewis and David Askin and Volante, \{R. P.\} and Reider, \{Paul J.\}",

year = "1998",

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doi = "10.1016/S0040-4039(98)01670-0",

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journal = "Tetrahedron Letters",

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T1 - Efficient synthesis of N-arylpiperazinones via a selective intramolecular Mitsunobu cyclodehydration

AU - Weissman, Steven A.

AU - Lewis, Stephanie

AU - Askin, David

AU - Volante, R. P.

AU - Reider, Paul J.

PY - 1998/10/8

Y1 - 1998/10/8

N2 - A practical two pot synthesis of N-arylpiperazinones from the corresponding aniline is described. The key transformation is a selective intramolecular Mitsunobu cyclodehydration of an amidoalcohol intermediate. A series of N-arylpiperazinones were prepared in yields up to 89%.

AB - A practical two pot synthesis of N-arylpiperazinones from the corresponding aniline is described. The key transformation is a selective intramolecular Mitsunobu cyclodehydration of an amidoalcohol intermediate. A series of N-arylpiperazinones were prepared in yields up to 89%.

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U2 - 10.1016/S0040-4039(98)01670-0

DO - 10.1016/S0040-4039(98)01670-0

M3 - Article

AN - SCOPUS:0032497606

SN - 0040-4039

VL - 39

SP - 7459

EP - 7462

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 41

ER -

Efficient synthesis of N-arylpiperazinones via a selective intramolecular Mitsunobu cyclodehydration

Abstract

All Science Journal Classification (ASJC) codes

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