Efficient synthesis of N-arylpiperazinones via a selective intramolecular Mitsunobu cyclodehydration

Steven A. Weissman, Stephanie Lewis, David Askin, R. P. Volante, Paul J. Reider

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

A practical two pot synthesis of N-arylpiperazinones from the corresponding aniline is described. The key transformation is a selective intramolecular Mitsunobu cyclodehydration of an amidoalcohol intermediate. A series of N-arylpiperazinones were prepared in yields up to 89%.

Original languageEnglish (US)
Pages (from-to)7459-7462
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number41
DOIs
StatePublished - Oct 8 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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