A practical two pot synthesis of N-arylpiperazinones from the corresponding aniline is described. The key transformation is a selective intramolecular Mitsunobu cyclodehydration of an amidoalcohol intermediate. A series of N-arylpiperazinones were prepared in yields up to 89%.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Oct 8 1998|
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry