Abstract
A practical two pot synthesis of N-arylpiperazinones from the corresponding aniline is described. The key transformation is a selective intramolecular Mitsunobu cyclodehydration of an amidoalcohol intermediate. A series of N-arylpiperazinones were prepared in yields up to 89%.
Original language | English (US) |
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Pages (from-to) | 7459-7462 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 39 |
Issue number | 41 |
DOIs | |
State | Published - Oct 8 1998 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Drug Discovery
- Organic Chemistry