Efficient synthesis of 6-mono-bromo-1,1′-bi-2-naphthol

Dongwei Cai, Robert D. Larsen, Paul J. Reider

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Through mono-ester formation of 1,1′-bi-2-naphthol (BINOL) with pivaloyl chloride the selective mono-bromination was achieved cleanly on the other ring to afford 6-mono-bromo-1,1′-bi-2-naphthol in an efficient 86% yield.

Original languageEnglish (US)
Pages (from-to)4055-4057
Number of pages3
JournalTetrahedron Letters
Issue number22
StatePublished - May 27 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


  • 6-mono-bromo-1,1′-bi-2-naphthol
  • Bromination

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