Efficiency and ambiguity in an adaptive neural code

A. L. Fairhall, G. D. Lewen, W. Bialek, R. R. De Ruyter van Steveninck

Research output: Contribution to journalArticle

514 Scopus citations

Abstract

We examine the dynamics of a neural code in the context of stimuli whose statistical properties are themselves evolving dynamically. Adaptation to these statistics occurs over a wide range of timescales - from tens of milliseconds to minutes. Rapid components of adaptation serve to optimize the information that action potentials Carry about rapid stimulus variations within the local statistical ensemble, while changes in the rate and statistics of action-potential firing encode information about the ensemble itself, thus resolving potential ambiguities. The speed with which information is optimized and ambiguities are resolved approaches the physical limit imposed by statistical sampling and noise.

Original languageEnglish (US)
Pages (from-to)787-792
Number of pages6
JournalNature
Volume412
Issue number6849
DOIs
StatePublished - Aug 23 2001

All Science Journal Classification (ASJC) codes

  • General

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    Fairhall, A. L., Lewen, G. D., Bialek, W., & De Ruyter van Steveninck, R. R. (2001). Efficiency and ambiguity in an adaptive neural code. Nature, 412(6849), 787-792. https://doi.org/10.1038/35090500