Effervescent redispersion of lyophilized polymeric nanoparticles

Carlos E. Figueroa, Douglas H. Adamson, Robert K. Prud'Homme

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Background: Freeze-drying is an attractive method for converting nanoparticulate pharmaceutical dispersions into a stable form with a long shelf life. However, practical challenges in translating laboratory practice to the clinic, such as high protectant osmolarity and infeasible reconstitution methods, currently limit lyophilized formulation development of nanoparticle therapeutics. Results: We demonstrate the use of effervescent redispersion for the reconstitution of lyophilized polymeric nanoparticles and we show that a 3:1 mass ratio of effervescent salt produced the optimum redispersibility. With only low-energy hand agitation, reconstitution to sizes less than 600 nm was achieved. Second, the effect of nanoparticle formulation parameters (dispersion concentration, molecular weight of the stabilizing polymer, and physical state of the nanoparticle core) on particle redispersibility were examined. Conclusion: This novel freeze-drying and reconstitution method offers a route to producing redispersible dry powders of nanoparticle therapeutics.

Original languageEnglish (US)
Pages (from-to)177-190
Number of pages14
JournalTherapeutic Delivery
Volume4
Issue number2
DOIs
StatePublished - Feb 1 2013

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'Effervescent redispersion of lyophilized polymeric nanoparticles'. Together they form a unique fingerprint.

  • Cite this