TY - JOUR
T1 - Effects of the peer metagenomic environment on smoking behavior
AU - Sotoudeh, Ramina
AU - Harris, Kathleen Mullan
AU - Conley, Dalton
N1 - Publisher Copyright:
© 2019 National Academy of Sciences. All rights reserved.
PY - 2019/8/13
Y1 - 2019/8/13
N2 - Recent scholarship suggests that the genomes of those around us affect our own phenotypes. Much of the empirical evidence for such “metagenomic” effects comes from animal studies, where the socio-genetic environment can be easily manipulated. Among humans, it is more difficult to identify such effects given the nonrandom distribution of genes and environments. Here we leverage the as-if-random distribution of grade-mates’ genomes conditional on school-level variation in a nationally representative sample. Specifically, we evaluate whether one’s peers’ genetic propensity to smoke affects one’s own smoking behavior net of one’s own genotype. Results show that peer genetic propensity to smoke has a substantial effect on an individual’s smoking outcome. This is true not only when the peer group includes direct friends, and therefore where the individual plays an active role in shaping the metagenomic context but also when the peer group includes all grade-mates and thus in cases where the individual does not select the metagenomic environment. We explore these effects further and show that a small minority with high genetic risk to smoke (‘bad apples’) can greatly affect the smoking behavior of an entire grade. The methodology used in this paper offers a potential solution to many of the challenges inherent in estimating peer effects in nonexperimental settings and can be utilized to study a wide range of outcomes with a genetic basis. On a policy level, our results suggest that efforts to reduce adolescent smoking should take into account metagenomic effects, especially bad apples, within social networks.
AB - Recent scholarship suggests that the genomes of those around us affect our own phenotypes. Much of the empirical evidence for such “metagenomic” effects comes from animal studies, where the socio-genetic environment can be easily manipulated. Among humans, it is more difficult to identify such effects given the nonrandom distribution of genes and environments. Here we leverage the as-if-random distribution of grade-mates’ genomes conditional on school-level variation in a nationally representative sample. Specifically, we evaluate whether one’s peers’ genetic propensity to smoke affects one’s own smoking behavior net of one’s own genotype. Results show that peer genetic propensity to smoke has a substantial effect on an individual’s smoking outcome. This is true not only when the peer group includes direct friends, and therefore where the individual plays an active role in shaping the metagenomic context but also when the peer group includes all grade-mates and thus in cases where the individual does not select the metagenomic environment. We explore these effects further and show that a small minority with high genetic risk to smoke (‘bad apples’) can greatly affect the smoking behavior of an entire grade. The methodology used in this paper offers a potential solution to many of the challenges inherent in estimating peer effects in nonexperimental settings and can be utilized to study a wide range of outcomes with a genetic basis. On a policy level, our results suggest that efforts to reduce adolescent smoking should take into account metagenomic effects, especially bad apples, within social networks.
KW - Adolescent smoking
KW - Social genetic effects
KW - Sociogenomics
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U2 - 10.1073/pnas.1806901116
DO - 10.1073/pnas.1806901116
M3 - Article
C2 - 31363050
AN - SCOPUS:85070587918
SN - 0027-8424
VL - 116
SP - 16302
EP - 16307
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 33
ER -