Abstract
The effects of various doses of d-amphetamine on behavior and striatal unit activity were studied in freely moving cats. Contrary to previous studies, conducted in anesthetized and/or immobilized animals, reporting, that striatal neurons were slow firing or silent, these neurons often displayed a high rate of discharge in the awake freely moving animal. Also contrary to much of the previous literature in immobolized animals, high doses of amphetamine (5.0 mg/kg i.p.) produced exclusively excitatory effects on striatal neurons, while lower doses (0.5 and 2.0 mg/kg) had both excitatory and inhibitory effects. In general, the behavioral stereotypy and hyperactivity tended to far outlast both types of neuronal changes.
Original language | English (US) |
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Pages (from-to) | 735-738 |
Number of pages | 4 |
Journal | Neuropharmacology |
Volume | 18 |
Issue number | 8-9 |
DOIs | |
State | Published - 1979 |
All Science Journal Classification (ASJC) codes
- Cellular and Molecular Neuroscience
- Pharmacology