Effective lithiation of 3-bromopyridine: Synthesis of 3-pyridine boronic acid and variously 3-substituted pyridines

Dongwei Cai, Robert D. Larsen, Paul J. Reider

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

By using toluene as a solvent, 3-lithiopyridine can be generated cleanly at -50°C. The addition of various electrophiles affords useful building blocks, such as the 3-pyridine boronic acid in 87% isolated yield.

Original languageEnglish (US)
Pages (from-to)4285-4287
Number of pages3
JournalTetrahedron Letters
Volume43
Issue number23
DOIs
StatePublished - Jun 3 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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