Effect of two dopamine receptor blockers on a serotonin-mediated behavioral syndrome in rats

Barry L. Jacobs

doi:10.1016/0014-2999(74)90014-4

Effect of two dopamine receptor blockers on a serotonin-mediated behavioral syndrome in rats

Barry L. Jacobs

Psychology

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Apomorphine (5 mg/kg) produces a behavioral syndrome in the rat, consisting of sniffing, chewing and locomotion. Dopamine receptor blockers spiroperidol and pimozide effectively block this syndrome (ED₅₀ for spiroperidol between 0.125 and 0.250 mg/kg and for pimozide 0.5 mg/kg). L-tryptophan (150 mg/kg) given to a pargyline (50 mg/kg) pretreated rat produces a syndrome consisting of tremor, rigidity, forepaw treading and head weaving. This 'serotonergic' syndrome can be blocked by spiroperidol (ED_{50 0.75 mg/kg}), but pimozide in doses as high as 10 mg/kg is ineffective. These data indicate that some dopamine receptor blockers also affect serotonin receptors, whereas others do not.

Original language	English (US)
Pages (from-to)	363-366
Number of pages	4
Journal	European Journal of Pharmacology
Volume	27
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(74)90014-4
State	Published - Aug 1974

All Science Journal Classification (ASJC) codes

Pharmacology

Keywords

Apomorphine
Dopamine receptors
Pargyline-L-tryptophan syndrome
Pimozide
Serotonin receptors
Spiroperidol

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10.1016/0014-2999(74)90014-4

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title = "Effect of two dopamine receptor blockers on a serotonin-mediated behavioral syndrome in rats",

abstract = "Apomorphine (5 mg/kg) produces a behavioral syndrome in the rat, consisting of sniffing, chewing and locomotion. Dopamine receptor blockers spiroperidol and pimozide effectively block this syndrome (ED50 for spiroperidol between 0.125 and 0.250 mg/kg and for pimozide 0.5 mg/kg). L-tryptophan (150 mg/kg) given to a pargyline (50 mg/kg) pretreated rat produces a syndrome consisting of tremor, rigidity, forepaw treading and head weaving. This 'serotonergic' syndrome can be blocked by spiroperidol (ED50 0.75 mg/kg), but pimozide in doses as high as 10 mg/kg is ineffective. These data indicate that some dopamine receptor blockers also affect serotonin receptors, whereas others do not.",

keywords = "Apomorphine, Dopamine receptors, Pargyline-L-tryptophan syndrome, Pimozide, Serotonin receptors, Spiroperidol",

author = "Jacobs, {Barry L.}",

note = "Funding Information: This research was supported by grants MH 24771 and MH 23433 from the National Institute of Mental Health. I would like to thank the companies indicated by asterisks in the Drug section for their generous gifts. I thank Daniel Ruimy and Donna Kirk for their assistance. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1974",

month = aug,

doi = "10.1016/0014-2999(74)90014-4",

language = "English (US)",

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pages = "363--366",

journal = "European Journal of Pharmacology",

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AU - Jacobs, Barry L.

N1 - Funding Information: This research was supported by grants MH 24771 and MH 23433 from the National Institute of Mental Health. I would like to thank the companies indicated by asterisks in the Drug section for their generous gifts. I thank Daniel Ruimy and Donna Kirk for their assistance. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1974/8

Y1 - 1974/8

N2 - Apomorphine (5 mg/kg) produces a behavioral syndrome in the rat, consisting of sniffing, chewing and locomotion. Dopamine receptor blockers spiroperidol and pimozide effectively block this syndrome (ED50 for spiroperidol between 0.125 and 0.250 mg/kg and for pimozide 0.5 mg/kg). L-tryptophan (150 mg/kg) given to a pargyline (50 mg/kg) pretreated rat produces a syndrome consisting of tremor, rigidity, forepaw treading and head weaving. This 'serotonergic' syndrome can be blocked by spiroperidol (ED50 0.75 mg/kg), but pimozide in doses as high as 10 mg/kg is ineffective. These data indicate that some dopamine receptor blockers also affect serotonin receptors, whereas others do not.

AB - Apomorphine (5 mg/kg) produces a behavioral syndrome in the rat, consisting of sniffing, chewing and locomotion. Dopamine receptor blockers spiroperidol and pimozide effectively block this syndrome (ED50 for spiroperidol between 0.125 and 0.250 mg/kg and for pimozide 0.5 mg/kg). L-tryptophan (150 mg/kg) given to a pargyline (50 mg/kg) pretreated rat produces a syndrome consisting of tremor, rigidity, forepaw treading and head weaving. This 'serotonergic' syndrome can be blocked by spiroperidol (ED50 0.75 mg/kg), but pimozide in doses as high as 10 mg/kg is ineffective. These data indicate that some dopamine receptor blockers also affect serotonin receptors, whereas others do not.

KW - Apomorphine

KW - Dopamine receptors

KW - Pargyline-L-tryptophan syndrome

KW - Pimozide

KW - Serotonin receptors

KW - Spiroperidol

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DO - 10.1016/0014-2999(74)90014-4

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C2 - 4472582

AN - SCOPUS:0016138182

SN - 0014-2999

VL - 27

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EP - 366

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 3

ER -

Effect of two dopamine receptor blockers on a serotonin-mediated behavioral syndrome in rats

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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