Effect of two dopamine receptor blockers on a serotonin-mediated behavioral syndrome in rats

Barry L. Jacobs

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Apomorphine (5 mg/kg) produces a behavioral syndrome in the rat, consisting of sniffing, chewing and locomotion. Dopamine receptor blockers spiroperidol and pimozide effectively block this syndrome (ED50 for spiroperidol between 0.125 and 0.250 mg/kg and for pimozide 0.5 mg/kg). L-tryptophan (150 mg/kg) given to a pargyline (50 mg/kg) pretreated rat produces a syndrome consisting of tremor, rigidity, forepaw treading and head weaving. This 'serotonergic' syndrome can be blocked by spiroperidol (ED50 0.75 mg/kg), but pimozide in doses as high as 10 mg/kg is ineffective. These data indicate that some dopamine receptor blockers also affect serotonin receptors, whereas others do not.

Original languageEnglish (US)
Pages (from-to)363-366
Number of pages4
JournalEuropean Journal of Pharmacology
Volume27
Issue number3
DOIs
StatePublished - Aug 1974

All Science Journal Classification (ASJC) codes

  • Pharmacology

Keywords

  • Apomorphine
  • Dopamine receptors
  • Pargyline-L-tryptophan syndrome
  • Pimozide
  • Serotonin receptors
  • Spiroperidol

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