Effect of microwave heating on Ullmann-type heterocycle-aryl ether synthesis using chloro-heterocycles

Noel D. D'Angelo, Joseph J. Peterson, Shon K. Booker, Ingrid Fellows, Celia Dominguez, Randall Hungate, Paul J. Reider, Tae Seong Kim

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Ullmann ether synthesis was conducted on a variety of chloro-heterocycles with different phenols using optimized conditions involving copper powder and cesium carbonate. On many substrates, microwave heating afforded higher yields in significantly shorter reaction times compared to conventional heating conditions. These findings provide a facile method for aryl ether synthesis from chloropyridines, chloroquinolines, and chlorobenzothiazoles.

Original languageEnglish (US)
Pages (from-to)5045-5048
Number of pages4
JournalTetrahedron Letters
Volume47
Issue number29
DOIs
StatePublished - Jul 17 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Keywords

  • Microwave
  • Ullmann ether synthesis

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    D'Angelo, N. D., Peterson, J. J., Booker, S. K., Fellows, I., Dominguez, C., Hungate, R., Reider, P. J., & Kim, T. S. (2006). Effect of microwave heating on Ullmann-type heterocycle-aryl ether synthesis using chloro-heterocycles. Tetrahedron Letters, 47(29), 5045-5048. https://doi.org/10.1016/j.tetlet.2006.05.103