Effect of microwave heating on Ullmann-type heterocycle-aryl ether synthesis using chloro-heterocycles

Noel D. D'Angelo; Joseph J. Peterson; Shon K. Booker; Ingrid Fellows; Celia Dominguez; Randall Hungate; Paul J. Reider; Tae Seong Kim

doi:10.1016/j.tetlet.2006.05.103

Effect of microwave heating on Ullmann-type heterocycle-aryl ether synthesis using chloro-heterocycles

Noel D. D'Angelo, Joseph J. Peterson, Shon K. Booker, Ingrid Fellows, Celia Dominguez, Randall Hungate, Paul J. Reider, Tae Seong Kim

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Ullmann ether synthesis was conducted on a variety of chloro-heterocycles with different phenols using optimized conditions involving copper powder and cesium carbonate. On many substrates, microwave heating afforded higher yields in significantly shorter reaction times compared to conventional heating conditions. These findings provide a facile method for aryl ether synthesis from chloropyridines, chloroquinolines, and chlorobenzothiazoles.

Original language	English (US)
Pages (from-to)	5045-5048
Number of pages	4
Journal	Tetrahedron Letters
Volume	47
Issue number	29
DOIs	https://doi.org/10.1016/j.tetlet.2006.05.103
State	Published - Jul 17 2006
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

Keywords

Microwave
Ullmann ether synthesis

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10.1016/j.tetlet.2006.05.103

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title = "Effect of microwave heating on Ullmann-type heterocycle-aryl ether synthesis using chloro-heterocycles",

abstract = "Ullmann ether synthesis was conducted on a variety of chloro-heterocycles with different phenols using optimized conditions involving copper powder and cesium carbonate. On many substrates, microwave heating afforded higher yields in significantly shorter reaction times compared to conventional heating conditions. These findings provide a facile method for aryl ether synthesis from chloropyridines, chloroquinolines, and chlorobenzothiazoles.",

keywords = "Microwave, Ullmann ether synthesis",

author = "D'Angelo, {Noel D.} and Peterson, {Joseph J.} and Booker, {Shon K.} and Ingrid Fellows and Celia Dominguez and Randall Hungate and Reider, {Paul J.} and Kim, {Tae Seong}",

year = "2006",

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doi = "10.1016/j.tetlet.2006.05.103",

language = "English (US)",

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T1 - Effect of microwave heating on Ullmann-type heterocycle-aryl ether synthesis using chloro-heterocycles

AU - D'Angelo, Noel D.

AU - Peterson, Joseph J.

AU - Booker, Shon K.

AU - Fellows, Ingrid

AU - Dominguez, Celia

AU - Hungate, Randall

AU - Reider, Paul J.

AU - Kim, Tae Seong

PY - 2006/7/17

Y1 - 2006/7/17

N2 - Ullmann ether synthesis was conducted on a variety of chloro-heterocycles with different phenols using optimized conditions involving copper powder and cesium carbonate. On many substrates, microwave heating afforded higher yields in significantly shorter reaction times compared to conventional heating conditions. These findings provide a facile method for aryl ether synthesis from chloropyridines, chloroquinolines, and chlorobenzothiazoles.

AB - Ullmann ether synthesis was conducted on a variety of chloro-heterocycles with different phenols using optimized conditions involving copper powder and cesium carbonate. On many substrates, microwave heating afforded higher yields in significantly shorter reaction times compared to conventional heating conditions. These findings provide a facile method for aryl ether synthesis from chloropyridines, chloroquinolines, and chlorobenzothiazoles.

KW - Microwave

KW - Ullmann ether synthesis

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UR - http://www.scopus.com/inward/citedby.url?scp=33744970285&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2006.05.103

DO - 10.1016/j.tetlet.2006.05.103

M3 - Article

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SN - 0040-4039

VL - 47

SP - 5045

EP - 5048

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 29

ER -

Effect of microwave heating on Ullmann-type heterocycle-aryl ether synthesis using chloro-heterocycles

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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