Effect of indolealkylamine manipulations on locomotor activity in rats

B. L. Jacobs, E. E. Eubanks, W. D. Wise

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The effect of various manipulations of the indolealkylamine system upon locomotor activity in adult male rats was investigated. 6-fluorotryptophan, a rapidly acting tryptophan hydroxylase inhibitor, produced a small, but significant decrease in activity. Neither variations in the dietary content of l-tryptophan, nor systemic injections of l-tryptophan had any effect on activity. However, pretreatment with the monoamine oxidase inhibitor, pargyline, caused l-tryptophan injections to produce a syndrome characterized by large increases in activity, tremor, rigidity, hyper-reactivity, streotyped head movements, and a general sympathetic response. Pretreatment with spiroperidol, a presumed specific dopamine receptor blocker, abolished all signs of the syndrome except for the rigidity and hyper-reactivity. By contrast, the noradrenergic receptor blockers, phenoxybenzamine and propanolol, had no observable effect on the syndrome.

Original languageEnglish (US)
Pages (from-to)575-583
Number of pages9
Issue number7
StatePublished - Jul 1974

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Pharmacology


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