Effect of buspirone on single unit activity in locus coeruleus and dorsal raphe nucleus in behaving cats

Lynn O. Wilkinson, Elizabeth D. Abercrombie, Kurt Rasmussen, Barry L. Jacobs

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The effects of administration of the non-benzodiazepine anxiolytic buspirone on the spontaneous and sensory evoked single unit activity of serotonergic (5-HT) neurons in the dorsal raphe nucleus and noradrenergic (NE) neurons in the locus coeruleus were examined in freely moving cats. Buspirone (1.0 mg/kg i.p.) strongly suppressed both the spontaneous and evoked activity of 5-HT dorsal raphe nucleus neurons. The spontaneous activity of NE neurons in the locus coeruleus was non-significantly increased by drug administration, while the evoked response was unaffected. These effects occurred during a period of mild behavioral activation. It is suggested that the anxiolytic effects of buspirone administration are not achieved through an action of NE neurons, but may be mediated in part by actions of 5-HT neurons in the dorsal raphe.

Original languageEnglish (US)
Pages (from-to)123-127
Number of pages5
JournalEuropean Journal of Pharmacology
Volume136
Issue number1
DOIs
StatePublished - Apr 7 1987

All Science Journal Classification (ASJC) codes

  • Pharmacology

Keywords

  • Anxiety
  • Anxiolytic drugs
  • Norepinephrine
  • Serotonin

Fingerprint Dive into the research topics of 'Effect of buspirone on single unit activity in locus coeruleus and dorsal raphe nucleus in behaving cats'. Together they form a unique fingerprint.

Cite this