Effect of buspirone on single unit activity in locus coeruleus and dorsal raphe nucleus in behaving cats

Lynn O. Wilkinson; Elizabeth D. Abercrombie; Kurt Rasmussen; Barry L. Jacobs

doi:10.1016/0014-2999(87)90789-8

Effect of buspirone on single unit activity in locus coeruleus and dorsal raphe nucleus in behaving cats

Lynn O. Wilkinson, Elizabeth D. Abercrombie, Kurt Rasmussen, Barry L. Jacobs

Psychology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The effects of administration of the non-benzodiazepine anxiolytic buspirone on the spontaneous and sensory evoked single unit activity of serotonergic (5-HT) neurons in the dorsal raphe nucleus and noradrenergic (NE) neurons in the locus coeruleus were examined in freely moving cats. Buspirone (1.0 mg/kg i.p.) strongly suppressed both the spontaneous and evoked activity of 5-HT dorsal raphe nucleus neurons. The spontaneous activity of NE neurons in the locus coeruleus was non-significantly increased by drug administration, while the evoked response was unaffected. These effects occurred during a period of mild behavioral activation. It is suggested that the anxiolytic effects of buspirone administration are not achieved through an action of NE neurons, but may be mediated in part by actions of 5-HT neurons in the dorsal raphe.

Original language	English (US)
Pages (from-to)	123-127
Number of pages	5
Journal	European Journal of Pharmacology
Volume	136
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(87)90789-8
State	Published - Apr 7 1987

All Science Journal Classification (ASJC) codes

Pharmacology

Keywords

Anxiety
Anxiolytic drugs
Norepinephrine
Serotonin

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10.1016/0014-2999(87)90789-8

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title = "Effect of buspirone on single unit activity in locus coeruleus and dorsal raphe nucleus in behaving cats",

abstract = "The effects of administration of the non-benzodiazepine anxiolytic buspirone on the spontaneous and sensory evoked single unit activity of serotonergic (5-HT) neurons in the dorsal raphe nucleus and noradrenergic (NE) neurons in the locus coeruleus were examined in freely moving cats. Buspirone (1.0 mg/kg i.p.) strongly suppressed both the spontaneous and evoked activity of 5-HT dorsal raphe nucleus neurons. The spontaneous activity of NE neurons in the locus coeruleus was non-significantly increased by drug administration, while the evoked response was unaffected. These effects occurred during a period of mild behavioral activation. It is suggested that the anxiolytic effects of buspirone administration are not achieved through an action of NE neurons, but may be mediated in part by actions of 5-HT neurons in the dorsal raphe.",

keywords = "Anxiety, Anxiolytic drugs, Norepinephrine, Serotonin",

author = "Wilkinson, {Lynn O.} and Abercrombie, {Elizabeth D.} and Kurt Rasmussen and Jacobs, {Barry L.}",

note = "Funding Information: This research was supported by National Institute of Mental Health Grant MH23433 and US Airforce Grant AFOSR 85-0034. The authors wish to thank Bristol Meyers for providing the buspirone used in these experiments.",

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doi = "10.1016/0014-2999(87)90789-8",

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T1 - Effect of buspirone on single unit activity in locus coeruleus and dorsal raphe nucleus in behaving cats

AU - Wilkinson, Lynn O.

AU - Abercrombie, Elizabeth D.

AU - Rasmussen, Kurt

AU - Jacobs, Barry L.

N1 - Funding Information: This research was supported by National Institute of Mental Health Grant MH23433 and US Airforce Grant AFOSR 85-0034. The authors wish to thank Bristol Meyers for providing the buspirone used in these experiments.

PY - 1987/4/7

Y1 - 1987/4/7

N2 - The effects of administration of the non-benzodiazepine anxiolytic buspirone on the spontaneous and sensory evoked single unit activity of serotonergic (5-HT) neurons in the dorsal raphe nucleus and noradrenergic (NE) neurons in the locus coeruleus were examined in freely moving cats. Buspirone (1.0 mg/kg i.p.) strongly suppressed both the spontaneous and evoked activity of 5-HT dorsal raphe nucleus neurons. The spontaneous activity of NE neurons in the locus coeruleus was non-significantly increased by drug administration, while the evoked response was unaffected. These effects occurred during a period of mild behavioral activation. It is suggested that the anxiolytic effects of buspirone administration are not achieved through an action of NE neurons, but may be mediated in part by actions of 5-HT neurons in the dorsal raphe.

AB - The effects of administration of the non-benzodiazepine anxiolytic buspirone on the spontaneous and sensory evoked single unit activity of serotonergic (5-HT) neurons in the dorsal raphe nucleus and noradrenergic (NE) neurons in the locus coeruleus were examined in freely moving cats. Buspirone (1.0 mg/kg i.p.) strongly suppressed both the spontaneous and evoked activity of 5-HT dorsal raphe nucleus neurons. The spontaneous activity of NE neurons in the locus coeruleus was non-significantly increased by drug administration, while the evoked response was unaffected. These effects occurred during a period of mild behavioral activation. It is suggested that the anxiolytic effects of buspirone administration are not achieved through an action of NE neurons, but may be mediated in part by actions of 5-HT neurons in the dorsal raphe.

KW - Anxiety

KW - Anxiolytic drugs

KW - Norepinephrine

KW - Serotonin

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JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

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ER -

Effect of buspirone on single unit activity in locus coeruleus and dorsal raphe nucleus in behaving cats

Abstract

All Science Journal Classification (ASJC) codes

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