Ecology and evolution of the flu

David J.D. Earn, Jonathan Dushoff, Simon Asher Levin

Research output: Contribution to journalReview article

183 Scopus citations

Abstract

Influenza (flu) is a common infectious disease, but it is unusual in that the primary timescales for disease dynamics (epidemics) and viral evolution (new variants) are roughly the same. Recently, extraordinarily reliable phylogenetic reconstructions of flu virus evolution have been made using samples from both extant and extinct strains. In addition, because of their public health importance, flu epidemics have been monitored throughout the period over which the phylogenetic trees extend. In parallel with this empirical work, theoretical ecologists have developed mathematical and computational models that elucidate many properties of multistrain systems. In the future, to unravel and interpret the complex interactions between ecological and evolutionary forces on flu dynamics, the documented evolution of the virus must be related to the observed population dynamics of the disease. New theoretical insights are also required to simplify model structures and facilitate predictions that can be tested with accessible data.

Original languageEnglish (US)
Pages (from-to)334-340
Number of pages7
JournalTrends in Ecology and Evolution
Volume17
Issue number7
DOIs
StatePublished - Jul 1 2002

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics

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