TY - JOUR
T1 - Ecology and evolution of the flu
AU - Earn, David J.D.
AU - Dushoff, Jonathan
AU - Levin, Simon Asher
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 2002/7/1
Y1 - 2002/7/1
N2 - Influenza (flu) is a common infectious disease, but it is unusual in that the primary timescales for disease dynamics (epidemics) and viral evolution (new variants) are roughly the same. Recently, extraordinarily reliable phylogenetic reconstructions of flu virus evolution have been made using samples from both extant and extinct strains. In addition, because of their public health importance, flu epidemics have been monitored throughout the period over which the phylogenetic trees extend. In parallel with this empirical work, theoretical ecologists have developed mathematical and computational models that elucidate many properties of multistrain systems. In the future, to unravel and interpret the complex interactions between ecological and evolutionary forces on flu dynamics, the documented evolution of the virus must be related to the observed population dynamics of the disease. New theoretical insights are also required to simplify model structures and facilitate predictions that can be tested with accessible data.
AB - Influenza (flu) is a common infectious disease, but it is unusual in that the primary timescales for disease dynamics (epidemics) and viral evolution (new variants) are roughly the same. Recently, extraordinarily reliable phylogenetic reconstructions of flu virus evolution have been made using samples from both extant and extinct strains. In addition, because of their public health importance, flu epidemics have been monitored throughout the period over which the phylogenetic trees extend. In parallel with this empirical work, theoretical ecologists have developed mathematical and computational models that elucidate many properties of multistrain systems. In the future, to unravel and interpret the complex interactions between ecological and evolutionary forces on flu dynamics, the documented evolution of the virus must be related to the observed population dynamics of the disease. New theoretical insights are also required to simplify model structures and facilitate predictions that can be tested with accessible data.
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U2 - 10.1016/S0169-5347(02)02502-8
DO - 10.1016/S0169-5347(02)02502-8
M3 - Review article
AN - SCOPUS:0036643943
SN - 0169-5347
VL - 17
SP - 334
EP - 340
JO - Trends in Ecology and Evolution
JF - Trends in Ecology and Evolution
IS - 7
ER -