Early life social stress induced changes in depression and anxiety associated neural pathways which are correlated with impaired maternal care

Christopher A. Murgatroyd, Catherine J. Peña, Giovanni Podda, Eric J. Nestler, Benjamin C. Nephew

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Exposures to various types of early life stress can be robust predictors of the development of psychiatric disorders, including depression and anxiety. The objective of the current study was to investigate the roles of the translationally relevant targets of central vasopressin, oxytocin, ghrelin, orexin, glucocorticoid, and the brain-derived neurotrophic factor (BDNF) pathway in an early chronic social stress (ECSS) based rodent model of postpartum depression and anxiety. The present study reports novel changes in gene expression and extracellular signal related kinase (ERK) protein levels in the brains of ECSS exposed rat dams that display previously reported depressed maternal care and increased maternal anxiety. Decreases in oxytocin, orexin, and ERK proteins, increases in ghrelin receptor, glucocorticoid and mineralocorticoid receptor mRNA levels, and bidirectional changes in vasopressin underscore related work on the adverse long-term effects of early life stress on neural activity and plasticity, maternal behavior, responses to stress, and depression and anxiety-related behavior. The differences in gene and protein expression and robust correlations between expression and maternal care and anxiety support increased focus on these targets in animal and clinical studies of the adverse effects of early life stress, especially those focusing on depression and anxiety in mothers and the transgenerational effects of these disorders on offspring.

Original languageEnglish (US)
Pages (from-to)103-111
Number of pages9
JournalNeuropeptides
Volume52
DOIs
StatePublished - 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

Keywords

  • Anxiety
  • Depression
  • Early life stress
  • Ghrelin
  • Mineralocorticoid receptor
  • Neuroplasticity
  • Orexin
  • Oxytocin
  • Postpartum depression
  • Vasopressin

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